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\dateposted{2024-10-23}
\begin{document}

\begin{noXML}

%\makeatletter
%\def\TITREspecial{\relax}
%\def\cdr@specialtitle@english{Breaking Barriers in Chemical Biology -- Toulouse 2022}
%\def\cdr@specialtitle@french{Briser les barri\`eres entre la chimique et la biologie -- Toulouse 2022}
%\makeatother

\CDRsetmeta{articletype}{foreword}

\title{Foreword---Breaking barriers in chemical biology: the innovative
tour de force of the  ChemBio GDR}

\alttitle{Avant-propos --- Briser les barri\`{e}res entre la chimie et
la biologie : l'innovant tour de force du GDR ChemBio}

\author{\firstname{Marie} \lastname{Lopez}\CDRorcid{0000-0001-7479-4657}\IsCorresp}
\address{CNRS-Universit\'{e} de Montpellier-ENSCM UMR 5247, Institut des Biomol\'{e}cules Max Mousseron (IBMM), 34296 Montpellier, France} 
\email[M. Lopez]{marie.lopez@cnrs.fr}


\author{\firstname{Elisabetta} \lastname{Mileo}\CDRorcid{0000-0002-0883-6043}}
\address{Aix Marseille Univ, CNRS, BIP, Bio\'{e}nerg\'{e}tique et Ing\'{e}nierie des Prot\'{e}ines, IMM, Marseille, France} 
\email[E. Mileo]{emileo@imm.cnrs.fr}


\author{\firstname{Eric} \lastname{Defrancq}\CDRorcid{0000-0002-3911-6241}}
\address{UMR 5250, D\'{e}partement de Chimie Mol\'{e}culaire, Universit\'{e} Grenoble Alpes, Grenoble, France} 
\email[E. Defrancq]{eric.defrancq@univ-grenoble-alpes.fr}


\author{\firstname{Agn\`{e}s} \lastname{Delmas}\CDRorcid{0000-0002-8243-8887}}
\address{CNRS UPR4301, Centre de biophysique Mol\'{e}culaire (CBM), Orl\'{e}ans, France} 
\email[A. Delmas]{agnes.delmas@cnrs-orleans.fr}


\author{\firstname{Boris} \lastname{~Vauzeilles}\CDRorcid{0000-0002-1815-8768}}
\address{Universit\'{e} Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France} 
\email[B. Vauzeilles]{boris.vauzeilles@cnrs.fr}


\author{\firstname{Dominique} \lastname{Guianvarc'h}\CDRorcid{0000-0002-7722-370X}}
\address{Universit\'{e} Paris-Saclay, CNRS, Institut de Chimie Mol\'{e}culaire et des Mat\'{e}riaux d'Orsay, UMR 8182, 91405, Orsay, France} 
\email[D. Guianvarc'h]{dominique.guianvarch@universite-paris-saclay.fr}


\author{\firstname{Christophe} \lastname{Biot}\CDRorcid{0000-0002-7396-1959}\IsCorresp}
\address{Universit\'{e} de Lille, CNRS, UMR 8576, UGSF, Unit\'{e} de Glycobiologie Structurale et Fonctionnelle (UGSF), F-59000, Lille, France}
\email[C. Biot]{christophe.biot@univ-lille.fr}

\shortrunauthors

\begin{abstract}
Chemical Biology can be defined as the design and the development of
molecular tools to decipher or modulate biological processes of
interest so that they can be better understood, controlled or modified.
It also consists in the observation and analysis of these molecular
tools within, and in interaction with, their complex biological
environment.
Chemical Biology can then lead to highly valuable basic knowledge and
be applied in diverse fields such as health and environment. Therefore,
Chemical Biology has strong interactions with the design of therapeutic
strategies, diagnosis, agrochemicals or Ecology.
\end{abstract}


\begin{altabstract}
La ch\'{e}mobiologie peut \^{e}tre d\'{e}finie comme la conception et le
d\'{e}veloppement d'outils mol\'{e}culaires pour d\'{e}coder ou moduler des
processus biologiques d'int\'{e}r\^{e}t en vue de les comprendre, de les
ma\^{\i}triser ou de les modifier. Elle implique \'{e}galement l'observation et
l'analyse de ces outils mol\'{e}culaires au sein de leur environnement
biologique complexe, ainsi que de leurs interactions avec ce dernier.
La ch\'{e}mobiologie peut ainsi conduire \`{a} des connaissances fondamentales
de grande valeur et \^{e}tre appliqu\'{e}e dans divers domaines tels que la
sant\'{e}, l'environnement ou l'agriculture. Par cons\'{e}quent, la
ch\'{e}mobiologie entretient des interactions \'{e}troites avec la conception
de strat\'{e}gies th\'{e}rapeutiques, le diagnostic, les produits agrochimiques
et l'\'{e}cologie.
\end{altabstract}


\keywords{\kwd{Interdisciplinary research}
\kwd{Molecular tools}
\kwd{Biological environment}
\kwd{Translational applications}
\kwd{Innovative strategies}}

\altkeywords{\kwd{Recherche interdisciplinaire}
\kwd{Outils mol\'{e}culaires}
\kwd{Environnement biologique}
\kwd{Application translationnelle}
\kwd{Strat\'{e}gies innovantes}}

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\end{noXML}

\section{ChemBio GDR genesis}

In 2018, the Deputy Scientific Director of the National Centre for
Scientific Research (CNRS) mandated us to organize a scientific event
to assess the expertise of French scientific community in different
research and application areas of Chemical Biology, as part of the
scientific policy of the CNRS-Institute of Chemistry (INC) and the
``Convergence Actions'' program. The events, called the Scientific Days
of Chemical Biology, were held in Lille in 2018 and then Nice in 2020.
It was an opportunity for a prospective reflection, which resulted in
January 2021 in the creation of the GDR 2095---ChemBio directed by
Professor Christophe Biot (UGSF, Lille). The aim of the ChemBio GDR is to
bring together scientists from the French Chemical Biology community,
which includes about 80 laboratories and 600 members, making it the
second largest GDR supported by the CNRS-INC. Aiming to support
exchanges of scientific expertise and skills for chemists and
biologists, ChemBio GDR is a fertile place for discussion leading to
the emergence of new key scientific questions. 


Just after its creation, the first ChemBio GDR scientific meeting was
held in Grenoble in October 2021, and the second one took place in
Toulouse in June 2022. The upcoming scientific meetings will be held in
Strasbourg in June 2023 and in Bordeaux in 2024. In addition to these
annual days dedicated to scientific exchange through oral, poster
presentations, and round tables on various topics, the ChemBio GDR
supports and is closely associated to the CNRS ChemBio thematic school
directed by Professor Dominique Guianvarc'h (Paris Saclay University,
ICMMO). This intensive one-week formation was first organized in
November 2021 in Le Touquet. Due to the success of the first edition, a
second edition, also supported by the ChemBio GDR, will be organized in
November 2023.



At the same time, in September 2019, considering the importance and the
impact of the French Chemical Biology, the Thematic Group of
Ch\'{e}mobiologie (SCF-ChemBio) was created within the French Chemical
Society (SCF). This group currently has more than 500 members and is
presided by Dr. Boris Vauzeilles (DR CNRS, ICSN). SCF-ChemBio
collaborates with ChemBioChem (Chemistry Europe, Wiley) and the
International Chemical Biology Society (ICBS) with which two e-symposia
were co-organised in April 2021 and July 2021. Besides, in 2021,
SCF-ChemBio also joined the European Federation for Medicinal chemistry
and Chemical biology (EFMC). In 2021, SFBBM (French Society for
Biochemistry and Molecular Biology) has introduced a new session
entitled ``\textit{Ch\'{e}mobiologie}'' for its annual meeting that takes
place every early July.


\section{ChemBio GDR objectives}

The ChemBio GDR has several objectives aimed at unifying Chemical
Biology research in France and increasing its visibility and
recognition (Box~\Custref{1}{box1}). One of the primary objectives is to connect
researchers and teams across the country and establish a network that
fosters the sharing of experiences, skills, and the launch of new
research dynamics. GDRs are valuable coordination structures that have
proven to be successful for several years.

Collaboration is another strength of the ChemBio GDR, and the
complementary expertise and knowledge of participating researchers and
teams contribute to the creation of fruitful collaborations and
international projects. The ChemBio GDR is also involved in student
training, including the organization of scientific workshops and
on-site training through its platforms. The ChemBio GDR supports
short-term scientific missions for PhD students between partner
laboratories to acquire specific expertise and/or techniques.

The ChemBio GDR has a further objective of increasing awareness about
technology transfer among researchers, especially those who are at the
early stages of their careers.

Moreover, the ChemBio GDR also seeks to promote creativity
and expand the borders of scientific culture by promoting interactions
between national artists and ChemBio GDR researchers. This initiative
encourages innovative methods for the progression of knowledge and
subsequent transfer to society. By exploring the aesthetic dimensions
of Chemical Biology and evaluating the outcome from the perspective of
the non-scientific community, members can improve media diffusion
practices and encourage a shift in practices based on scientific
challenges towards the artistic community.

\onecolumngrid

\unskip\noindent\begin{frtextbox}{Box 1---ChemBio GDR is articulated around 3 thematic axes}
\enlabel{box1}
\mbox{}

\vspace*{-10pt}


\begin{enumerate}[(1)]
\leftskip=-1.3pc
\item Chemical targeting and modulation, understanding of biological
processes: By developing molecular tools that can scan and modulate
biological processes of interest, researchers in Chemical Biology are
able to better understand and control those processes for a variety of
applications.

\item Chemical tools and molecular approaches: Using a range of chemical
tools and molecular approaches, researchers in Chemical Biology are
able to design and develop new compounds and therapies for a wide range
of applications, from drug discovery to agriculture.

\item Physicochemical technologies: Advancements in physicochemical
technologies enable researchers in Chemical Biology to better study the
complex interactions between molecules and biological systems, leading
to new discoveries and breakthroughs in a variety of
fields.
\end{enumerate}

\end{frtextbox}

\vspace*{10pt}
\twocolumngrid



\section{2nd ChemBio GDR scientific days}

The 2nd ChemBio GDR Scientific Days took place on June 8th and 9th,
2022 at the University of Toulouse III. This 2022 edition was closely
related to the annual Chemistry--Biology--Health day in Toulouse, held on
June 10th, 2022, which demonstrated the impact of chemical biology on
the study and treatment of human diseases. The event had 148
registrations and spanned two days and was the opportunity to attend
three plenary conferences, 14 lectures, 11 flash-talks, and two poster
sessions. This special edition of ``Comptes Rendus Chimie'' is an
opportunity to share with the scientific community the
multidisciplinary research of the speakers who presented at this 2nd
ChemBio GDR Scientific Days.
\vspace*{-.2em}

\onecolumngrid
%\vspace*{.8em}

\xxfigure{fx01}{}
\vspace*{1em}
\twocolumngrid

In this special issue on French Chemical Biology, we bring together a
collection of cutting-edge research articles and reviews that highlight
recent advances and exciting new directions in the field. It should be
emphasized that the selection for this special issue was limited to the
speakers who presented their work in Toulouse. Therefore, only the
\mbox{articles/reviews} from those speakers have been chosen for publication.

{\vspace*{1.2pc}}

\section*{Conflicts of interest}

%{\vspace*{-.5pc}}

Authors have no conflict of interest to declare.


\onecolumngrid
\xxfigure{fx02}{}

\vspace*{2pc}

\twocolumngrid

\begin{xxminipage}
\textit{Axis 1---Chemical targeting and modulation, understanding of biological processes}

Marie-Pierre Rols (Toulouse)

H\'{e}l\`{e}ne Munier-Lehmann (Paris)

Ludger Johannes (Paris)

Laurence Lafanech\`{e}re (Grenoble)

\vspace*{6pt}

\textit{Axis 2---Chemical tools and molecular approaches}

Eric Defrancq (Grenoble)

Marie Lopez (Montpellier)

Sylvain Routier (Orl\'{e}ans)

\vspace*{6pt}

\textit{Axis 3---Physicochemical technologies}

Agn\`{e}s Delmas (Orl\'{e}ans)

Carine Van-Heijenoort (Paris Saclay)

Vladimir Torbeev (Strasbourg)

\end{xxminipage}

\vfill\eject

\begin{xxminipage}

\vspace*{4.42cm}

\textbf{Webmaster}

Elisabetta Mileo (Marseille) 

Jean-Marc Sache (Grenoble)

\textbf{Web site}

\url{www.gdr.chemobiologie.cnrs.fr/}

\end{xxminipage}

\back{}

\end{document}
