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\DOI{10.5802/crchim.323}
\datereceived{2024-06-18}
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%\def\TITREspecial{\relax}
%\def\cdr@specialtitle@english{Breaking Barriers in Chemical Biology -- Toulouse 2022}
%\def\cdr@specialtitle@french{Briser les barri\`eres entre la chimique et la biologie -- Toulouse 2022}
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\title{Guest Editors}

\alttitle{R\'{e}dacteurs en chef invit\'{e}s}

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\noindent
\textbf{Marie Lopez} obtained her PhD in chemo-enzymatic synthesis of
oligosaccharides in 2007 under the supervision of Dr. H. Driguez and Dr.
A. Bul\'{e}on. In 2008, she joined Poulsen's group (GRIDD, Brisbane) as
a post-doctoral fellow to work on glycosylated carbonic anhydrase
inhibitors. In a second post-doctoral position, she worked on
anti-tuberculosis agents in Montpellier before being recruited, in
2013, as a CNRS research scientist at the ETaC laboratory in Toulouse,
directed by Paola B. Arimondo, to work on DNA methylation and its
implication in cancers. In 2016, she moved to the IBMM in Montpellier,
managing a research group working in chemistry, biochemistry and
chemical biology to decipher and target epigenetic modifications in
pathological contexts. Her projects consist in identifying new
strategies to target epigenetic mechanism, i.e. multivalent,
multifunctional and hybrid inhibitors, ProTaCs, peptide-based
inhibitors and in developing affinity-based chemical probes to
understand epigenetic mechanism in diverse context, i.e. cancer,
infectious diseases, invertebrate models. In 2020 she was elected as a
member of the scientific board of the \textit{Ch\'{e}mobiologie} group
of the \textit{Soci\'{e}t\'{e} Chimique de France} (SCF-ChemBio). Since
2021 she has been a member of the scientific committee of the ChemBio
GDR.

\bigskip

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\noindent
\textbf{Elisabetta Mileo} is a CNRS researcher at the laboratory
``Bioenergetique et Ingenierie des Prot\'{e}ines'' (BIP) in Marseille.
She is a chemist and a spectroscopist with experience in the synthesis
and use of nitroxide radicals as spin probes and spin labels in
supramolecular chemistry and applied to structural biology. She
obtained her PhD in 2010 at the University of Bologna (Italy) under the
supervision of Professor Marco Lucarini in the field of self-assembled
supramolecular architectures investigated by Electron Paramagnetic
Resonance (EPR) spectroscopy. During her PhD, she joined the group of
Professor A. E. Kaifer, during 6 months (Miami, Florida) investigating the
self-assembly of resorcinarene capsules. After a postdoctoral fellow in
the group of Professor S. Marque (ICR, Marseille, France, 2010) working on
the synthesis of new nitroxide-based spin labels for selective Tyrosine
labeling, she joined the group of Professor B. Guigliarelli in 2012 at the
BIP laboratory (Marseille, France) and her scientific interests shifted
towards the investigation of protein structural dynamics by
Site-Directed Spin Labelling coupled to EPR spectroscopy (SDSL-EPR). In
2014, she obtained a full position as CNRS researcher (Marseille,
France). Since 2014, E. Mileo research activities are mainly focused on
the investigation of protein structural dynamics, in particular in
chaperones and other flexible proteins, with the objective of gaining
information on how protein dynamics affects protein function. The
originality of her work resides on the fact that protein investigation
by SDSL-EPR is carried directly inside cells (in-cell EPR), in
physiological conditions. Her studies are also aimed to the development
of new tools and new spin labels to follow proteins ``in action'' by
EPR directly into living cells.

\bigskip

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\noindent
After obtaining a PhD in Chemistry in 1989 at the University J.~Fourier
of Grenoble (UJF), \textbf{Eric Defrancq} realized a post-doctoral
internship at the Institute of Chemistry of Neuch\^{a}tel (Switzerland)
in the field of the chemistry of natural substances. In 1992, he was
appointed lecturer at the UJF at the LEDSS and in 2004 he became a
university professor.
The common thread of his research is the Chemical-Biology. In this
context, he carries out his research activities within the Department
of Molecular Chemistry (DCM-UMR CNRS 5250) at the University of
Grenoble Alpes and within the laboratory, he is the scientific
coordinator of the Chemical Engineering of Nucleic Acids group.
His research themes relate more particularly to the development of
high-performance chemical methods for incorporating a motif into a
nucleic acid (DNA or RNA) in order to provide it with new properties.
In particular, in recent years, he has been interested in specific DNA
structures: G-quadruplexes and i-motifs which constitute new biological
targets. In this context, he has developed an original concept (named
TASQ for Template Assisted Synthetic G-Quadruplex) to constrain the
topology of these tetrameric DNAs. These biomolecular systems are then
used for the design and study of new photo-activable metal complexes
targeting G-quadruplex DNA, the production of specific antibodies for
G-quadruplex DNA and for the study of proteins interacting with these
DNA.
He is also director of the Institute of Molecular Chemistry of Grenoble
(ICMG -- UAR 2602) and scientific advisor to Hc\'{e}res.

\bigskip

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\noindent
\textbf{Agn\`{e}s Delmas}, a pharmacist by training, is Director of Research
Emeritus at the CNRS. Her scientific career, between chemistry and
biology, was pursued at the Centre of Molecular Biophysics
(Orl\'{e}ans), where she has promoted and structured a team focused on
the chemistry of synthetic proteins. After two decades at the head of
the peptide synthesis research group, she joined the NMR thematic
group, which she led until 2020. Her role in facilitating collaborative
research between the synthesis and NMR groups has highlighted the
thematic axis focused on the synthesis and structural study of
naturally occurring peptides/proteins rich in disulfide bridges.
In addition to her scientific work, Agn\`{e}s Delmas was the director
of the doctoral school, of the Physics and Chemistry of Life federation
and President of Section 16 of the CNRS, always seeking to promote
research in chemical biology.

\clearpage

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\noindent
An alumnus of the Ecole Normale Sup\'{e}rieure in Paris,
\textbf{Boris~Vauzeilles} prepared his PhD under the supervision of 
Professor Pierre
Sina\"{y} in the chemistry department of this institution. He then
joined Professor Julius Rebek, Jr. at MIT (Cambridge, Massachussets), for a
post-doctoral experience. The group soon moved to the Scripps Research
Institute in La Jolla, where Julius Rebek was promoted to Director of
the Skaggs Institute for Chemical Biology. Boris Vauzeilles then
returned to France as a CNRS researcher (Institut de Chimie
Mol\'{e}culaire et des Mat\'{e}riaux d'Orsay, Universit\'{e}
Paris-Saclay), and in 2012, in parallel to his research at Orsay,
created a new team at the Institut de Chimie des Substances Naturelles
\`{a} Gif-sur-Yvette, where he founded the Chemical Biology Department
in 2015. He is also co-founder of a startup company, Diamidex, and
received, with his group, the Prix La Recherche in 2015. His research
is primarily focused on using synthetic chemistry to develop molecular
tools to probe biological processes. Since 2020, he has been the
director of the Institute of Chemistry of Natural Substances. He chairs
the Chemical Biology Group of the French Chemical Society
(SCF-ChemBio), and is on the Board of Directors of the International
Chemical Biology Society.

\bigskip

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\noindent
\textbf{Dominique Guianvarc'h} received a formation in Biochemistry and
Organic Chemistry from the University Pierre et Marie Curie in Paris.
She received her PhD in Organic Chemistry in 2001 under the supervision
of Professor Jean-Louis Fourrey at the Institut de Chimie des
Substances Naturelles in Gif sur Yvette (France) on
\textit{C}-nucleosides and nucleic acids chemistry. She then pursued a
post-doctoral training in the laboratory of Biophysics of Professor
Claude H\'{e}l\`{e}ne at the Museum National d'Histoire Naturelle in
Paris on the development of oligonucleotide-conjugated topoisomerase
inhibitors. In 2003, she was recruited as Associate Professor in the
laboratory of Biomolecules founded by Professor Andr\'{e}e Marquet at
the University Pierre et Marie Curie. In 2007, she developed her own
group devoted to the study of methyltransferases enzymes with chemical
tools. In 2017, she was promoted Professor at the University Paris
Saclay at the Institut de Chimie Mol\'{e}culaire et des Mat\'{e}riaux
d'Orsay (France). She is group leader of a team in Bioorganic Chemistry
with complementary skills in carbohydrate and nucleic acid chemistry,
protein engineering and enzymology. Her research interests are in the
areas of chemical biology including the development of chemical probes
to understand different biological issues involving enzymes with
potential applications in the field of health. In 2020, she was elected
as board member and scientific secretary of the Chemical Biology Group
within the French Chemical Society. Since 2021, she has been deputy
director of the CNRS french research consortium in Chemical Biology
(GDR-ChemBio). She is strongly involved in trainings with
\mbox{interdisciplinary} programs and created a CNRS Thematic School of
Chemical Biology in 2021.

\clearpage

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\noindent
\textbf{Christophe Biot} obtained his PhD in bioorganometallics in
1998 under the supervision of Pr. J. Brocard. Following several
post-doctoral positions, he joined the University of Lille as an
assistant professor in 2004. He is currently a Professor and leads the
Chemical GlycoBiology (CheGB) team at the Unity of Structural and
Functional Glycobiology. The team comprises scientists with diverse
expertise ranging from organic synthesis to cell biology, and their
research topics encompass a broad range of significant areas in
chemical biology. Biot has published more than 130 research articles
and 15 book chapters. Christophe Biot is the \mbox{director} of the GDR
ChemBio.

\end{document}
