[Simulation de la cicatrisation osseuse avec des échafaudages bio-résorbables dans un système tridimensionnel : aperçus sur la résorption et l’intégration des greffes]
Cette étude présente un modèle tridimensionnel (3D) destiné à explorer les interactions entre le tissu osseux trabéculaire et les greffes bio-résorbables, en se concentrant sur leur rôle dans les processus de remodelage osseux. En s’appuyant sur les principes de la poroélasticité, le modèle reproduit le comportement mécanique de l’os et de la greffe en tant que milieux poreux, dont l’interaction est influencée par des charges mécaniques variables dans le temps et par des stimuli mécaniques diffusifs. Ces stimuli, issus de la densité d’énergie de déformation, se propagent à travers le système, déclenchant la formation osseuse et la résorption des greffes dans des régions éloignées. Les simulations numériques mettent en évidence l’impact déterminant de la fréquence et de l’intensité des charges sur l’efficacité du remodelage, des valeurs plus élevées favorisant une densité osseuse accrue et une meilleure intégration des greffes. Cette approche 3D fournit des informations précieuses pour optimiser la conception des échafaudages, offrant ainsi des recommandations utiles pour améliorer les résultats cliniques en matière de réparation et de régénération osseuse.
This study introduces a three-dimensional (3D) model for investigating the interactions between trabecular bone tissue and bio-resorbable grafts, focusing on their role in bone remodelling processes. Using principles of poroelasticity, the model captures the mechanical behaviour of both bone and graft as porous continua, with their interaction influenced by time-varying mechanical loads and diffusive mechanical stimuli. The stimuli, originating from the strain energy density, propagate through the system, triggering bone formation and graft resorption across distant regions. Numerical simulations reveal the critical impact of load frequency and intensity on remodelling efficiency, with higher values promoting improved bone density and graft integration. This 3D approach provides information on optimizing scaffold design, offering valuable guidance to improve clinical outcomes in bone repair and regeneration procedures.
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Mots-clés : Remodelage osseux, Interaction os–greffe, Échafaudage poreux résorbable, Lois de diffusion de Fick, Stimulus biomécanique
Rachele Allena 1, 2 ; Daria Scerrato 3, 4 ; Alberto Bersani 3, 4, 5 ; Ivan Giorgio 6, 4, 5
CC-BY 4.0
@article{CRMECA_2025__353_G1_479_0,
author = {Rachele Allena and Daria Scerrato and Alberto Bersani and Ivan Giorgio},
title = {Simulating bone healing with bio-resorbable scaffolds in a three-dimensional system: insights into graft resorption and integration},
journal = {Comptes Rendus. M\'ecanique},
pages = {479--497},
publisher = {Acad\'emie des sciences, Paris},
volume = {353},
year = {2025},
doi = {10.5802/crmeca.291},
language = {en},
}
TY - JOUR AU - Rachele Allena AU - Daria Scerrato AU - Alberto Bersani AU - Ivan Giorgio TI - Simulating bone healing with bio-resorbable scaffolds in a three-dimensional system: insights into graft resorption and integration JO - Comptes Rendus. Mécanique PY - 2025 SP - 479 EP - 497 VL - 353 PB - Académie des sciences, Paris DO - 10.5802/crmeca.291 LA - en ID - CRMECA_2025__353_G1_479_0 ER -
%0 Journal Article %A Rachele Allena %A Daria Scerrato %A Alberto Bersani %A Ivan Giorgio %T Simulating bone healing with bio-resorbable scaffolds in a three-dimensional system: insights into graft resorption and integration %J Comptes Rendus. Mécanique %D 2025 %P 479-497 %V 353 %I Académie des sciences, Paris %R 10.5802/crmeca.291 %G en %F CRMECA_2025__353_G1_479_0
Rachele Allena; Daria Scerrato; Alberto Bersani; Ivan Giorgio. Simulating bone healing with bio-resorbable scaffolds in a three-dimensional system: insights into graft resorption and integration. Comptes Rendus. Mécanique, Volume 353 (2025), pp. 479-497. doi : 10.5802/crmeca.291. https://comptes-rendus.academie-sciences.fr/mecanique/articles/10.5802/crmeca.291/
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