Approximation for limit cycles and their isochrons

Jacques Demongeot; Jean-Pierre Françoise

doi:10.1016/j.crvi.2006.05.005

Biological modelling / Biomodélisation

Approximation for limit cycles and their isochrons
[Approximation pour les cycles limites et leurs isochrones]

Présenté par : Michel Thellier

Jacques Demongeot ¹ ; Jean-Pierre Françoise ²

¹ Laboratoire TIMC, UMR CNRS 5525, faculté de médecine, université Joseph-Fourier de Grenoble, 38700 La Tronche, France
² Laboratoire Jacques-Louis-Lions, UMR CNRS 7598, université Pierre-et-Marie-Curie, Paris 6, site Chevaleret, 165, rue du Chevaleret, 75013 Paris, France

Comptes Rendus. Biologies, Volume 329 (2006) no. 12, pp. 967-970.

Résumés

Anglais
Français

Local analysis of trajectories of dynamical systems near an attractive periodic orbit displays the notion of asymptotic phase and isochrons. These notions are quite useful in applications to biosciences. In this note, we give an expression for the first approximation of equations of isochrons in the setting of perturbations of polynomial Hamiltonian systems. This method can be generalized to perturbations of systems that have a polynomial integral factor (like the Lotka–Volterra equation).

Pour analyser le comportement des trajectoires au voisinage des orbites périodiques attractives, les notions de phase asymptotique et d'isochrone apparaissent naturellement. Mais c'est leur importance dans les applications, en particulier dans les sciences de la vie (biologie, physiologie, pharmacocinétique, ...), qui a le plus fortement motivé leur étude. L'objet de cette note est de donner, dans le cadre des pertubations de systèmes hamiltoniens polynomiaux, une approximation au premier ordre pour les équations des isochrones. Cette méthode peut ensuite s'étendre à des perturbations de systèmes qui ont un facteur intégrant polynomial (comme l'équation de Lotka–Volterra).

Métadonnées

Reçu le : 2005-10-18
Accepté le : 2006-05-02
Publié le : 2006-09-08

PMID

DOI : 10.1016/j.crvi.2006.05.005

Keywords: Biological rhythms, Synchronization, Phaseless sets, Resetting curve
Mot clés : Rythmes biologiques, Synchronisation, Phase asymptotique

Affiliations des auteurs :

Jacques Demongeot ¹ ; Jean-Pierre Françoise ²

¹ Laboratoire TIMC, UMR CNRS 5525, faculté de médecine, université Joseph-Fourier de Grenoble, 38700 La Tronche, France
² Laboratoire Jacques-Louis-Lions, UMR CNRS 7598, université Pierre-et-Marie-Curie, Paris 6, site Chevaleret, 165, rue du Chevaleret, 75013 Paris, France

@article{CRBIOL_2006__329_12_967_0,
     author = {Jacques Demongeot and Jean-Pierre Fran\c{c}oise},
     title = {Approximation for limit cycles and their isochrons},
     journal = {Comptes Rendus. Biologies},
     pages = {967--970},
     publisher = {Elsevier},
     volume = {329},
     number = {12},
     year = {2006},
     doi = {10.1016/j.crvi.2006.05.005},
     language = {en},
}

TY  - JOUR
AU  - Jacques Demongeot
AU  - Jean-Pierre Françoise
TI  - Approximation for limit cycles and their isochrons
JO  - Comptes Rendus. Biologies
PY  - 2006
SP  - 967
EP  - 970
VL  - 329
IS  - 12
PB  - Elsevier
DO  - 10.1016/j.crvi.2006.05.005
LA  - en
ID  - CRBIOL_2006__329_12_967_0
ER  -

%0 Journal Article
%A Jacques Demongeot
%A Jean-Pierre Françoise
%T Approximation for limit cycles and their isochrons
%J Comptes Rendus. Biologies
%D 2006
%P 967-970
%V 329
%N 12
%I Elsevier
%R 10.1016/j.crvi.2006.05.005
%G en
%F CRBIOL_2006__329_12_967_0

Jacques Demongeot; Jean-Pierre Françoise. Approximation for limit cycles and their isochrons. Comptes Rendus. Biologies, Volume 329 (2006) no. 12, pp. 967-970. doi : 10.1016/j.crvi.2006.05.005. https://comptes-rendus.academie-sciences.fr/biologies/articles/10.1016/j.crvi.2006.05.005/

Version originale du texte intégral

1 Introduction

The interest for isochrons of limit cycles appeared first in relation with mathematics of biosciences. Their use was particularly emphazised by Winfree [1] and latter appeared repeatedly in many classical references related with biological rhythms [2–5]. Under the influence of Winfree's articles, Guckenheimer [6] identified the isochrons with the stable manifold of a point on an attractive hyperbolic limit cycle. Another proof of their existence and a discussion of the case of non-hyperbolic limit cycles appeared in [7]. M. Sabatini [8,9] proved that the existence of isochron sections for a limit cycle of a vector field X is equivalent to the existence of a vector field Y such that the bracket $[X, Y]$ is proportional to Y. More recently, the need for finding a closed formula for isochrons was frequently formulated in view of applications. In this article, we focus on a perturbative situation where the system is a perturbation of a polynomial Hamiltonian system:

\dot{x} = \frac{\partial H}{\partial y} + ϵ f (x, y, ϵ)

\dot{y} = - \frac{\partial H}{\partial x} + ϵ g (x, y, ϵ) .

We provide a closed form to the first-order approximation in ϵ for an equation of the limit cycles and for their isochrons. The essential idea is to use a one-parameter family of integrating factors. This method has been first used to compute the successive derivatives of return maps [10] and periods [11]. A more general and abstract setting has been recently proposed in [12]. This general mathematical setting uses iterated integrals and Leray residue. In this note, we stick to the first order of approximation and use only ramified integrals that are not iterated.

2 Definition of isochrons and of asymptotic phase

Existence of isochrons can be deduced from [13]. Let $γ : [0, T] \to R^{n}$ , $γ : t \mapsto γ (t)$ be an attractive hyperbolic periodic orbit and let Σ be a section transverse to the flow. First-return mapping writes:

P : x \mapsto x_{1} = A \cdot x + D (x)

with

a = ‖ A ‖ < 1

. Denote

x_{n}

, the successive intersection points of the orbit with the transverse section. Let τ be the time of first return to the transverse section along the orbit passing by x. Denote

τ_{1} = τ (x), \dots, τ_{n} = τ_{n - 1} + τ (x_{n})

. Function

τ (x)

is at least of class

C^{1}

, hence from x small enough, there is a constant L such that:

| τ (x_{n - 1}) - T | ⩽ L ‖ x ‖ ⩽ L a^{n - 1} ‖ x ‖

The series of general term

[(τ_{n} - n T) - (τ_{n - 1} - (n - 1) T)]

is normally convergent and thus the sequence

τ_{n} - n T

is convergent. The limit

t_{0} (x) = \lim_{n \to \infty} (τ_{n} - n T)

is called the asymptotic phase of the point x. Isochrons are defined by the equations:

{x | t_{0} (x) = c .}

3 One-parameter family of integrating factor and approximation to limit cycle

Given a one-form ω, a function H and a transverse section Σ, consider the continuous family of regular ovals $H = c$ , which fills up a domain homeomorphic to an annulus denoted A.

Define the ramified primitive $f_{1} (P) : A - Σ \to R$ of ω:

f_{1} (P) = \oint_{P_{0} (t)}^{P} ω

where the integral is taken along the solution

H (x, y) = H (P) = t

of the Hamiltonian flow between the first intersection point

P_{0} (t)

of the solution with the transverse section and the point P.

Define the polynomial D by

d ω = D (x, y) d x \land d y

Given a polynomial H, there always exists a polynomial

m (H)

that belongs to the Jacobian ideal of H (cf. [12]). There is a 1-form, unique up to a multiple of dH,

\tilde{ω}

, such that:

m (H) d x \land d y = \tilde{ω} \land d H

and take:

ω_{1} = D (x, y) \frac{\tilde{ω}}{m (H)}

Define finally the function $g_{1}$ as:

g_{1} = \oint ω_{1}

We have thus obtained that any polynomial one-form ω can be written

ω = g_{1} d H + d f_{1}

with ramified functions

f_{1}

and

g_{1}

. The function

f_{1}

is kind of primitive of the form ω along the level lines of H. The function

- g_{1}

is a primitive of the Leray derivative of ω, and this can be conveniently denoted

d g_{1} = - \frac{d ω}{d H}

.

This construction yields (recursively) a construction of a 1-parameter family of integrating factor (cf. [12]). We stick here to the first-order approximation, which displays

(1 - ϵ g_{1}) (d H + ϵ ω) = d (H + ϵ f_{1}) + O (ϵ^{2})

This approximation provides an approximation to an equation of an eventual limit cycle as:

H + ϵ f_{1} = c

Note that

f_{1}

is ramified, but (up to

O (ϵ^{2})

) the ramified part of

f_{1}

vanishes identically on the limit cycle. Thus this formal construction usually yields a tractable expression for this approximation, as it will appear more clearly in the foregoing example.

4 Van der Pol oscillator

Consider the van der Pol oscillator:

\dot{x} = y

\dot{y} = - x + ϵ F (x) y

where

F (x) = x^{2} - 1

. The case of Liénard equations where F can be any polynomial can be treated completely similarly.

The associated foliation of the plane can be defined by the 1-form $d H + ϵ ω$ , $ω = - F (x) y d x$ . We obtain in that case:

f_{1} = [\frac{{(x^{2} + y^{2})}^{2}}{8} - \frac{(x^{2} + y^{2})}{2}] Arctan (\frac{y}{x}) + \frac{x y^{3}}{8} - \frac{x^{3} y}{8} + \frac{x y}{2}

This is a ramified function but the limit cycle sits (up to terms of order

O (ϵ)

) near the circle

[\frac{{(x^{2} + y^{2})}^{2}}{8} - \frac{(x^{2} + y^{2})}{2}] = 0

Hence the first approximation to the equation for the limit cycle that we obtain is of the form:

\frac{x^{2} + y^{2}}{2} + ϵ [\frac{x y^{3}}{8} - \frac{x^{3} y}{8} + \frac{x y}{2}] = c

5 Isochronous forms to a vector field

Assume that $X_{0}$ is a Hamiltonian planar vector field,

i_{X_{0}} d x \land d y = d H

Assume furthermore that H is polynomial and that for

c_{0} ⩽ c ⩽ c_{1}

, the level line

H^{−1} (c)

contains an oval

γ_{c}

(closed smooth compact curve). The ovals

γ_{c}

are periodic orbits of

X_{0}

of period

T_{c}

.

Definition 1

A 1-form $ω_{0}$ is said to be isochronous to $X_{0}$ if $ω_{0} (X_{0}) = 1$ , or equivalently $d H \land ω_{0} = d x \land d y$ .

For instance, if $H = \frac{1}{2} (x^{2} + y^{2})$ , then we can choose $ω_{0} = d θ = d Arctan \frac{y}{x}$ . In general, for any polynomial H, there is a polynomial $m (H)$ that belongs to the Jacobian ideal of H. This yields two polynomials p and q such that we can choose:

ω_{0} = [p d x + q d y] / m (H)

A polynomial H is said to be quasi-homogeneous if there are three integers d, m and n such that:

H = \frac{d}{m} \frac{\partial H}{\partial x} + \frac{d}{n} \frac{\partial H}{\partial y}

In that case, a possible choice is:

ω_{0} = [\frac{d}{m} d y - \frac{d}{n} d x] / H

Consider now a 1-parameter perturbation:

ω_{ϵ} = d H + ϵ ω

and the associated vector field

X_{ϵ}

defined by

i_{X_{ϵ}} d x \land d y = ω_{ϵ}

The following notion was first discussed in [11].

Definition 2

A 1-form $ω_{0} + ϵ ω_{1}$ is 1-isochronous to $ω_{ϵ}$ if:

(d H + ϵ ω) \land (ω_{0} + ϵ ω_{1}) = [1 + O (ϵ^{2})] d x \land d y .

Construction of a 1-isochronous form proceeds in the same way as above. The unknown form $ω_{1}$ must satisfy:

ω \land ω_{0} + d H \land ω_{1} = 0

and this 1-form can be formally defined as the Leray residue:

ω_{1} = - \frac{ω \land ω_{0}}{d H}

A transversal section to the flow of a vector field near a limit cycle is a section such that the first return time is constant. Guckenheimer pointed out the fact that the isochrons are permuted by the flow. Isochronous sections and isochrons are not exactly the same notions. For instance, in the case of the Hamiltonian flow, there is no limit cycle (and hence no isochrons), despite the fact that there may be isochronous sections if the Hamiltonian flow is isochronous. But if there is an hyperbolic attractive limit cycle and if there is an isochronous section, then it is of course an isochron. Our method displays an approximation for an isochronous section. If we denote:

f_{ϵ} = \oint (ω_{0} + ϵ ω_{1})

the ramified primitive of the 1-isochronous form, then an approximated equation for an isochronous section is:

f_{ϵ} = c

6 Isochrons for the van der Pol system

In the case of the van der Pol system, we obtain that:

ω_{0} = d θ

and

ω_{1} = (r^{2} \cos^{2} θ - 1) \sin θ \cos θ d θ

An approximated equation for isochrons is thus obtained as:

θ + ϵ [r^{2} (\frac{\cos^{4}}{4} - 1) + \frac{1}{2} \sin^{2} θ] = c

Acknowledgements

This article was motivated by discussions with P. Baconnier in Saint-Flour (France). Financial support of the ACI ‘Nouvelles interactions des mathématiques instantbio’, which made possible such interactions, is gratefully acknowledged.

Bibliographie

[1] A.T. Winfree The Geometry of Biological Time, Springer-Verlag, New York, 1980

[2] J. Murray Mathematical Biology, Biomathematics Texts, vol. 19, Springer-Verlag, Berlin, 1989

[3] A. Golbeter Biochemical Oscillations and Cellular Rhythms, Cambridge University Press, Cambridge, 1996

[4] J. Demongeot; F. Seydoux Sur l'approche théorique dans l'étude des régulations métaboliques, Bulletin du Groupement d'études des Ryhtmes biologiques, Volume 13 (1981), pp. 27-37

[5] J.-P. Françoise Oscillations en biologie, Collection « Mathématiques & Applications », Springer, Berlin, 2005

[6] J. Guckenheimer Isochrons and phaseless sets, J. Math. Biol., Volume 1 (1975), pp. 259-273

[7] C. Chicone; W. Liu Asymptotic phase revisited, J. Diff. Equat., Volume 204 (2004), pp. 227-246

[8] M. Sabatini, Isochronous sections via normalizers, Preprint, 2003

[9] M. Sabatini Characterizing isochronous centres by Lie brackets, Diff. Equat. Dyn. Syst., Volume 5 (1997), pp. 91-99

[10] J.-P. Françoise Successive derivatives of a first return mapping: application to quadratic vector fields, Ergodic Theor. Dyn. Syst., Volume 16 (1996), pp. 87-96

[11] J.-P. Françoise The successive derivatives of the period function of a plane vector field, J. Diff. Equat., Volume 146 (1998), pp. 320-335

[12] J.-P. Françoise; M. Pelletier Iterated integrals, Leray residue and first return map, J. Dyn. Control Syst., Volume 12 (2006) no. 3, pp. 357-369

[13] P. Hartman Ordinary Differential Equations, Wiley, New York, 1964

Commentaires - Politique