[Visualisation et quantification du flux sanguin dans l’arbre vasculaire carotidien par IRM en contraste de phase]
Purpose. The objective is to build a phase contrast (PC) MRI protocol, consistent with clinical practice, to provide a 3D blood flow visualization and quantification of hemodynamic parameters in the complete carotid vascular tree.
Methods. The protocol composed of 2D and 4D PC-MRI sequences was applied on 6 volunteers and then on one patient diagnosed with facial cancer to prove the feasibility of clinical translation. The vessel geometry was reconstructed from the 4D sequences and the hemodynamic parameters quantified in the common, internal and external carotids and in the facial artery. Wall shear stresses (WSS) were quantified from the 2D PC-MRI sequences to benefit from their higher resolution.
Results. Time evolution of the three-dimensional blood flow velocity and vorticity fields was successfully obtained in all the branches of the carotid vascular tree despite the large range of sizes. Consistent maps of blood flow distribution were provided by normalizing the local blood flows by that of the common carotid artery. They indicated that 72.4% (±3.9%) of blood flows into the internal carotid. WSS is higher in the internal (0.95 Pa at peak systole) than in the external carotid (0.53 Pa) and facial artery (0.15 Pa).
Conclusion. A PC-MRI protocol, applicable to patients, was designed to quantify hemodynamic parameters in vessels ranging from a few millimeters to the centimeter in diameter. It provided a complete characterization of the hemodynamic condition evolution along the carotid vascular tree, and reference values to be compared to in case of pathology.
Objectif. L’objectif est de développer un protocole d’IRM en contraste de phase (PC), compatible avec la pratique clinique, permettant une visualisation tridimensionnelle du flux sanguin et la quantification de paramètres hémodynamiques dans l’ensemble de l’arbre vasculaire carotidien.
Méthodes. Le protocole, composé de séquences d’IRM PC 2D et 4D, a été appliqué à 6 volontaires puis à un patient diagnostiqué avec un cancer facial afin de démontrer la faisabilité de la transposition clinique. La géométrie vasculaire a été reconstruite à partir des séquences 4D et les paramètres hémodynamiques ont été quantifiés dans les carotides commune, interne et externe, ainsi que dans l’artère faciale. Les contraintes de cisaillement pariétal (WSS) ont été quantifiées à partir des séquences PC-IRM 2D afin de bénéficier de leur résolution plus élevée.
Résultats. L’évolution temporelle des champs tridimensionnels de vitesse du flux sanguin et de vorticité a été obtenue avec succès dans toutes les branches de l’arbre vasculaire carotidien, malgré la grande variabilité des calibres vasculaires. Des cartes cohérentes de la distribution du flux sanguin ont été fournies en normalisant les flux locaux par celui de la carotide commune. Elles indiquent que 72,4 % (±3,9 %) du flux sanguin est dirigé vers la carotide interne. Les WSS sont plus élevées dans la carotide interne (0,95 Pa au pic systolique) que dans la carotide externe (0,53 Pa) et l’artère faciale (0,15 Pa).
Conclusion. Un protocole d’IRM en contraste de phase, applicable aux patients, a été conçu pour quantifier les paramètres hémodynamiques dans des vaisseaux dont le diamètre varie de quelques millimètres à un centimètre. Il permet une caractérisation complète de l’évolution des conditions hémodynamiques le long de l’arbre vasculaire carotidien et fournit des valeurs de référence pouvant être utilisées à des fins de comparaison en cas de pathologie.
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Mots-clés : Flux sanguin, IRM, Contraste de phase, Carotide, Contrainte de cisaillement pariétal
Gwenaël Pagé 1 ; Jérémie Bettoni 1 ; Olivier Balédent 1 ; Anne-Virginie Salsac 2
CC-BY 4.0
@article{CRMECA_2026__354_G1_35_0,
author = {Gwena\"el Pag\'e and J\'er\'emie Bettoni and Olivier Bal\'edent and Anne-Virginie Salsac},
title = {Blood flow visualization and quantification in the carotid vascular tree by phase contrast {MRI}},
journal = {Comptes Rendus. M\'ecanique},
pages = {35--52},
year = {2026},
publisher = {Acad\'emie des sciences, Paris},
volume = {354},
doi = {10.5802/crmeca.320},
language = {en},
}
TY - JOUR AU - Gwenaël Pagé AU - Jérémie Bettoni AU - Olivier Balédent AU - Anne-Virginie Salsac TI - Blood flow visualization and quantification in the carotid vascular tree by phase contrast MRI JO - Comptes Rendus. Mécanique PY - 2026 SP - 35 EP - 52 VL - 354 PB - Académie des sciences, Paris DO - 10.5802/crmeca.320 LA - en ID - CRMECA_2026__354_G1_35_0 ER -
%0 Journal Article %A Gwenaël Pagé %A Jérémie Bettoni %A Olivier Balédent %A Anne-Virginie Salsac %T Blood flow visualization and quantification in the carotid vascular tree by phase contrast MRI %J Comptes Rendus. Mécanique %D 2026 %P 35-52 %V 354 %I Académie des sciences, Paris %R 10.5802/crmeca.320 %G en %F CRMECA_2026__354_G1_35_0
Gwenaël Pagé; Jérémie Bettoni; Olivier Balédent; Anne-Virginie Salsac. Blood flow visualization and quantification in the carotid vascular tree by phase contrast MRI. Comptes Rendus. Mécanique, Volume 354 (2026), pp. 35-52. doi: 10.5802/crmeca.320
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