Electrochemical determination of naproxen in the presence of acetaminophen using a carbon paste electrode modified with activated carbon nanoparticles

Nasrin Soltani; Nahid Tavakkoli; Zinat S. Mosavimanesh; Fatemeh Davar

doi:10.1016/j.crci.2017.11.007

Electrochemical determination of naproxen in the presence of acetaminophen using a carbon paste electrode modified with activated carbon nanoparticles

Nasrin Soltani ¹ ; Nahid Tavakkoli ¹ ; Zinat S. Mosavimanesh ¹ ; Fatemeh Davar ²

¹ Department of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, Iran
² Department of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, Islamic Republic of Iran

Comptes Rendus. Chimie, Volume 21 (2018) no. 1, pp. 54-60.

Résumé

In this study, cyclic voltammetry and differential pulse voltammetry were used to determine the electrochemical properties and concentration of naproxen in pharmaceutical formulation and human serum samples by using a carbon paste electrode modified with activated carbon nanoparticles. Optimum conditions were obtained at an electrode with 0.005 g activated carbon nanoparticles in a phosphate buffer solution of pH 6 as a supporting electrolyte. Linear calibration curves were obtained in the range of 0.1–120 μM, and the detection limit of naproxen determined was 0.0234 μM. The modified electrode shows good selectivity for naproxen in the presence of some organic and inorganic interferences and very good precision in real samples. Finally, naproxen was measured in the presence of acetaminophen.

Métadonnées

Reçu le : 2017-09-10
Accepté le : 2017-11-23
Publié le : 2018-01-01

DOI : 10.1016/j.crci.2017.11.007

Keywords: Activated carbon nanoparticles, Voltammetry, Naproxen, Acetaminophen, Carbon paste electrode

Affiliations des auteurs :

Nasrin Soltani ¹ ; Nahid Tavakkoli ¹ ; Zinat S. Mosavimanesh ¹ ; Fatemeh Davar ²

¹ Department of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, Iran
² Department of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, Islamic Republic of Iran

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     author = {Nasrin Soltani and Nahid Tavakkoli and Zinat S. Mosavimanesh and Fatemeh Davar},
     title = {Electrochemical determination of naproxen in the presence of acetaminophen using a carbon paste electrode modified with activated carbon nanoparticles},
     journal = {Comptes Rendus. Chimie},
     pages = {54--60},
     publisher = {Elsevier},
     volume = {21},
     number = {1},
     year = {2018},
     doi = {10.1016/j.crci.2017.11.007},
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Nasrin Soltani; Nahid Tavakkoli; Zinat S. Mosavimanesh; Fatemeh Davar. Electrochemical determination of naproxen in the presence of acetaminophen using a carbon paste electrode modified with activated carbon nanoparticles. Comptes Rendus. Chimie, Volume 21 (2018) no. 1, pp. 54-60. doi : 10.1016/j.crci.2017.11.007. https://comptes-rendus.academie-sciences.fr/chimie/articles/10.1016/j.crci.2017.11.007/

Version originale du texte intégral

Le texte intégral ci-dessous peut contenir quelques erreurs de conversion par rapport à la version officielle de l'article publié.

1 Introduction

Naproxen [(+)-2-(6-methoxy-2-naphthyl)propionic acid] is an analgesic, anti-inflammatory, and antipyretic drug used in the treatment of rheumatoid arthritis, osteoarthritis, gout, nonrheumatic inflammation, and migraine. In some cases, it is also effective in reducing pain of orthopedic surgery, muscle cramps, and muscle stiffness [1]. Naproxen should be given with caution in elderly patients with kidney problems and in patients with inflammatory disease of the upper or lower channel of ear duct, hemophilia, platelet coagulation dysfunction, and gastrointestinal bleeding [1]. Different procedures have been developed for the determination of naproxen. They include capillary electrophoresis [2], spectrophotometric [3] and fluorometric determination [4–6], spectrofluorometry [7,8], second-derivative synchronous fluorescence spectroscopy [9], synchronous luminescence spectrometry [10], chemiluminescence [11,12], phosphorescence [13,14], high-performance liquid chromatography [15–19], and electrochemical techniques [20–25]. Among these methods, electrochemical techniques have received a lot of attention, as they are simple, economical, and precise. Because electrochemical measurement of pharmaceutical and biological compounds was not possible with conventional electrode because of overvoltage, electrodes were modified with nanoparticles. The nanostructure materials have different and important physical and chemical properties because of their nanoscale. Due to these features, nanomaterials can be used as a tool to develop and improve analytical processes. In this study, activated carbon nanoparticles (ACNPs) were used as a modifier. Activated carbon has a crystalline form, which is a good absorbent substance because it has a lot of pores in its internal structure [26]. This material is produced by the pyrolysis of organic materials and carbonaceous sources such as coal, peat, wood, sawdust, and nutshells, and its applications mainly depend on the raw material and the production process [27,28]. High internal surface area, high porosity, ability to absorb gases, and chemical liquids are unique features of activated carbon, which would render it as an excellent absorbent material used in the carbon electrode structure [29]. Therefore, using electrochemical methods by electrode modified with ACNPs, in addition to improving the surface of electrode for oxidation of drug and reducing the overvoltage, increases the sensitivity, accuracy, and selectivity of electrode. Determination of naproxen is the main aim of this study. On the basis of the conducted research, the use of a carbon paste electrode (CPE) modified with ACNPs has not been reported for the measurement of naproxen until now. Therefore, first, a modified CPE with ACNPs (ACNP/CPE) was made, and all parameters that can have effects on the current of naproxen (including instrumental and chemical parameters) were optimized; then, the naproxen in pharmaceutical and physiological samples is measured by using the prepared electrode. Measurement of naproxen in the presence of acetaminophen is another goal of this study. Therefore, finally, simultaneous measurement of acetaminophen and naproxen was done with modified electrode.

2 Experimental section

2.1 Chemicals and reagents

All of the chemical materials used in this study are listed in Table 1. As can be seen from Table 1, all reagents had analytical grades and were purchased from Merck (Darmstadt, Germany). ACNPs with an average size of 20–30 nm (Fig. 1) were purchased from Degussa Company. All solutions were freshly prepared with deionized water. Graphite powder and paraffin oil (DC350, density = 0.88 g cm⁻³), as binding agents (both from Merck), were used for preparing the pastes. The buffer solutions were prepared from orthophosphoric acid and its salts, and its pH range was between 2.0 and 9.0.

Chemical	Chemical formula	Purity (%)	Company
Acetic acid	C₂H₄O₂	100	Merck
Phosphoric acid	H₃PO₄	85	Merck
Sodium dihydrogen phosphate	NaH₂PO₄	99	Merck
Disodium hydrogen phosphate	Na₂HPO₄	99	Merck
Boric acid	H₃BO₃	99	Merck
Sodium hydroxide	NaOH	99	Merck
Naproxen	CH₃OC₁₀H₄CH(CH₃)CO₂H	99	Merck
Paraffin oil		100	Merck
Graphite powder	C	100	Merck
ACNPs	C	99	Degussa

Fig. 1
Scanning electron microscopy image of ACNPs.

2.2 Apparatus

In this study, an Autolab potentiostat PGSTAT 30 (Eco Chemie B.V., Netherlands) was used for electrochemical measurements including cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS), which contains a cell with three electrodes in the sample solution. These three electrodes are modified or unmodified CPE as working electrode, Ag/AgCl (3.0 M KCl) as reference electrode, and platinum wire as counter electrode. EIS experiments were obtained in the Fe²⁺/Fe³⁺ solution (0.1 M KCl solution containing 10 mM K₃Fe(CN)₆/K₄Fe(CN)₆), as the redox probe, at the open-circuit potential and over the frequency range of 0.01 Hz–100 kHz. Phosphate buffers with various pH values were made using Metrohome 827 pH meter. Analytical digital scale Skaltek SBA31 (d = 0.0001 g) was used to weigh chemicals, and Excel software was used to record the voltammogram curves and calculations.

2.3 CPE preparation

CPE, formed from the mixture of graphite powder with nonconductive organic compounds and insoluble materials in water, has a renewable surface, low price, and low current field. The composition of carbon paste is highly effective in electrode activity. For modification of carbon paste with ACNPs, first, 0.5 g of graphite powder was grinded in an agate mortar for 20 min. Then, 0.005 g of ACNPs were added to the graphite powder and after grinding for 20 min, about seven to eight drops of paraffin oil were added to it. The obtained homogeneous paste was compacted into an insulin syringe with a cross-section of 1.34 mm, and to connect the electrical device and drug solution in electrochemical measurements, a copper wire was imported into the carbon paste from the end of the syringe and was prepared to work with the electrochemical device.

3 Results and discussion

3.1 Definition of the appropriate amount of ACNPs for modification of electrode

Because ACNPs can affect the response of the electrode relative to naproxen, its amount was changed from 0.001 to −0.007 g, and CV and DPV of buffer solution, containing 10 μM of naproxen, were recorded. The results illustrated that the maximum current was obtained for the electrode with 0.005 g ACNPs and the current of electrodes containing 0.005, 0.006, and 0.007 g ACNPs is similar to 0.005 g ACNPs. Therefore, the electrode with 0.005 g ACNPs was chosen in the following experiments.

3.2 Electrochemical behavior of naproxen

To evaluate the efficacy and electrode resistance of modified and unmodified electrodes, cyclic voltammograms of these electrodes in the buffer solution without naproxen and with naproxen were investigated, and the results are shown in Fig. 2. The results show that modified electrode with drug and unmodified electrode without drug have maximum and minimum current heights, respectively. Fig. 2 curve c shows that the electrochemical response of naproxen on the surface of CPE has appeared in the potential of 0.936 V with I_pa = 0.45 μA, whereas for ACNP/CPE (Fig. 2, curve d), electrochemical signal of naproxen is observed in the potential of 0.932 V with I_pa = 1.7 μA. The small changes observed in peak potential indicate that ACNPs exhibit a slight catalytic effect. The oxidation current of naproxen on the ACNP/CPE surface is 4.5 times larger than on CPE. The reason for the observed high current in ACNP/CPE may be attributed to the characteristics of ACNPs such as high specific surface area and unique conductivity.

Fig. 2
Cyclic voltammograms for modified and unmodified electrodes. (a and b) Bare and modified electrodes in buffer solution. (c and d) Bare and modified electrodes in buffer solution with naproxen. Conditions: 50 μM naproxen, buffer phosphate 0.1 M at pH 6.

3.3 Investigation of electrode with EIS and CV methods

Impedance is an electrochemical technique, which investigates all the reactions of an electrode surface that happen in the frequency range and different potentials. In this study, to determine the resistance of unmodified and modified electrodes by ACNPs in the process of drug oxidation, the Nyquist plots of these electrodes were compared in Fe(CN)₃^3−/4− solution. According to the results (Fig. 3), modified electrode by ACNPs had lower resistance and better electron transfer rate with respect to the unmodified electrode. This illustrates that ACNPs have excellent electrical conductivity and let the electron transfer easier.

Fig. 3
Nyquist plot of unmodified and modified electrodes by ACNPs in Fe²⁺/Fe³⁺ solution.

To compare the active surface area of CPE and ACNP/CPE, the real surface area of each electrode was obtained by using the Randles–Sevcik equation (Eq. 1).

I_{pa} = 2.69 \times 105 n^{3 / 2} {AC}_{0} D^{1 / 2} v^{1 / 2}

(1)

For this purpose, cyclic voltammograms were drawn for each of the electrodes in a 0.1 M KCl solution containing 1 mM of K₃Fe (CN)₆ at different scan rates. In Eq. 1, I_pa, n, A, D, ν, and C₀ are anodic peak current, electron transfer number, surface area of electrode, diffusion coefficient, scan rate, and concentration of K₃Fe(CN)₆, respectively, where, for K₃Fe(CN)₆, n is equal to 1 and D is equal to 7.6 × 10⁻⁶ cm² s⁻¹. Therefore, using the slope of I_pa–ν^1/2 curve and the values of n and D, the surface areas of CPE and ACNP/CPE obtained were 0.039 and 0.121 cm², respectively. The results indicate that the surface area of ACNP/CPE is 3.1 times larger than that of CPE. The reason for increasing the surface area of ACNP/CPE can be attributed to the high specific surface area of the ACNPs.

3.4 Effect of the potential scan rate on the behavior of naproxen with CV method

To study the kinetic parameters including the determination of absorption or leakage of the process of drug oxidation on the surface of the CPE modified with ACNPs, the effect of the potential scan rate on the behavior of naproxen was investigated. In this way, cyclic voltammogram for drug was examined in the scan rate range of 30–130 mV, and the results are shown in Fig. 4a.

Fig. 4
(a) Cyclic voltammogram for 50 μM naproxen with ACNP/CPE in 0.1 M phosphate buffer solution at pH 6, (a–h) 30, 50, 80, 100, 110, 115, 120, and 130 mV s⁻¹; inset: variation of I_p versus square root of scan rate (ν^1/2). (b) Tafel curve of log current versus potential from the rising section of CV with a scan rate of 50 mV s⁻¹ obtained for 50 μM naproxen in 0.1 M phosphate buffer solution at pH 6.

The linearity of the relationship between I_p and ν^1/2 shows that the oxidation of naproxen on the surface of a modified electrode was controlled by mass transfer and the species penetrates into the electrode for the oxidation. Therefore, the electro-oxidation of naproxen on the surface of ACNP/CPE was associated with a fast electron transfer kinetic [30].

Tafel curve, which is used to obtain electron transfer coefficient (α), was obtained from the CV plot with a scan rate of 50 mV s⁻¹. The data of the rising section of CV identified as Tafel area were used for drawing Fig. 4b. The slope of the obtained Tafel curve is equal to (1 − α)nF/RT. By substituting the numerical values of n, F, R, and T in the slope of the Tafel curve, the amount of α for the oxidation of naproxen obtained was 0.85.

3.5 Effect of pH

Oxidation of drug profoundly depends on the pH of the sample solution. To determine pH optimum, the solutions of buffer phosphate were prepared in the pH range of 2.0–9.0. The voltammogram curves for determination of optimum pH with DPV method for CPE were obtained, and the results are presented in Fig. 5. The curves of peak current versus pH and peak potential versus pH are shown in Fig. 5band c, respectively. The results of Fig. 5b show that the maximum current has been obtained for pH 6.0. Therefore, phosphate buffer with pH 6 was selected as the optimum pH for subsequent experiments. As shown in Fig. 5c, the peak potential has a linear relationship with pH. It shows that the proton participates in the electrochemical reactions on the surface of the electrode and the change in pH causes the change in potential oxidation. In other words, the reaction was done in more positive potential by decreasing the pH and increasing the H⁺ ion concentration. The slope of linear equation in Fig. 5c is equal to 0.0563. This means that the number of protons and electrons participating in the oxidation reaction of naproxen is equal (Scheme 1) [24].

Fig. 5
(a) Differential pulse voltammogram curve for ACNP/CPE in 0.1 M phosphate buffer solution in the pH range 2–9, containing 50 μM naproxen, (a–i) 2, 3, 4, 5, 6, 7, 7.5, 8, and 9. (b) The effect of pH on the peak potential. (c) The effect of pH on the peak current of naproxen oxidation.

Scheme 1
Proposed mechanism for the oxidation of naproxen.

3.6 Calibration curve

To evaluate the quantitative and the detection limit in electrochemical methods, DPV method was used because it has higher sensitivity than CV. Because DPV parameters of the pulse height and the pulse width can affect the peak sensitivity and morphology, these parameters have been investigated, and the results show that the values 40 mV of the pulse height and 50 ms of the pulse width cause the most suitable DPV signal. The curves are obtained by different concentrations of naproxen, and the results are shown in Fig. 6. These results indicate that the current changes versus the concentration of naproxen were linear in the range of 0.1–120 μM, and the detection limit was 0.0234 μM.

Fig. 6
Differential pulse voltammogram for different concentrations of naproxen with ACNP/CPE in 0.1 M phosphate buffer solution at pH 6; (a–j) 0.1, 1.0, 3.0, 8.0, 15.0, 30.0, 50.0, 80.0, 100.0, and 120.0 μM. Inset represents current changes versus different concentrations of naproxen.

Linear dynamic range, detection limit, and sensitivity obtained for ACNP/CPE in this study are compared with some electrochemical methods reported for determination of naproxen in Table 2. According to Table 2, except DyNw/CPE, linear dynamic range and detection limit of ACNP/CPE are better than all electrodes presented in this table.

Electrode type	Determination method	Dynamic range	Detection limit	Sensitivity	Ref.
MWCNT/GCEs^a	Amperometric	10–100 mM	0.6 mM	0.394 μA μM⁻¹	[22]
MWCNT/msCYP1A2-SPE^b	Amperometric	9–300 mM	16.00 μM	0.54 μA/mM mm	[21]
MWCNT-Gr-IL\|CCE^c	DPV	0.8–100 μM	0.123 μM	0.3533 μA μM⁻¹	[24]
DyNW/CPE^d	Square wave voltammetry	0.001–500 μM	0.0005 μM	0.387 μA μM⁻¹	[23]
Platinum electrode	DPV	1–25 μg mL⁻¹	0.24 μg mL⁻¹	0.1142 μA mL μg⁻¹	[20]
ZnO/MWCNTs/CPE^e	Square wave voltammetry	1.0–200 μM	0.23 μM	0.256 μA μM⁻¹	[25]
ACNP/CPE^f	DPV	0.1–120 μM	0.0234 μM	0.0013 μA μM⁻¹	This work

^a Multiwalled carbon nanotubes (MWCNTs) modified glassy carbon electrode (GCE).

^b MWCNTs and microsomal cytochrome P4501A2 (msCYP1A2) on a graphite screen-printed electrode (SPE).

^c MWCNT–graphene hybrid combined with a hydrophobic ionic liquid (IL) as a binder to modify carbon ceramic electrode (CCE).

^d Dysprosium nanowire modified CPE.

^e ZnO nanoparticles and MWCNTs modified CPE.

^f Modified CPEs with activate carbon nanoparticles.

3.7 Effect of interferences

To evaluate the selectivity of the method, the effect of different species on anodic peak current of naproxen was examined, and the results are shown in Table 3. In these experiments, the used species were similar to the species in the physiological samples. Each species was first added to have the same concentration as that of naproxen, and then another addition causes the concentration of interfering to be increased. The tolerance limit was taken as the maximum concentration of the foreign substances, which caused an approximately ±5% relative error in determination of current. As can be seen in Table 3, the concentration of interference species is very high with respect to naproxen concentration. The results indicated that selectivity of the modified electrode for determination of naproxen is very good and can be easily used for real samples.

Species	The molar ratio of interference species to the concentration of naproxen
Ascorbic acid	800
Glycine	500
Citric acid	1000
Oxalate	800
Na⁺, K⁺, Mg²⁺, Ca²⁺	900
NO₃⁻, CO₃²⁻, Cl⁻	850
Fructose, sucrose, glucose	400
Aspirin	200

3.8 Reproducibility, repeatability, and stability of the modified electrode

The reproducibility of the preparation procedure of the modified CPE was estimated by determination of 10 μM naproxen solution using six independently prepared modified electrodes based on the same fabrication procedure, and the obtained relative standard deviation (RSD) values were 1.2%. Reproducibility in the preparation and determination procedure was affirmed by the obtained low RSD. The RSD of the peak currents of 10 μM naproxen for 15 repeated determinations with the same modified electrode was 0.26%. This indicates that repeatability of modified electrode for determination of naproxen is desirable. Stability of the modified CPE was examined by keeping the electrode in the buffer solution with pH 6.0 for 1, 2, and 3 weeks; after this time, the DPV of the electrode was compared with DPV of the electrode before immersion. The results indicated that even after 4 weeks of immersion, change in the peak current of naproxen was less than 5%, which indicated that the stability of the electrode was very good.

3.9 Determination of naproxen in pharmaceutical samples and human blood serum

To evaluate the efficacy of applied method in real samples, the content of naproxen in tablet (250 and 500 mg) was obtained by the standard addition method. The results are presented in Table 4. To investigate the effect of tissue of physiological samples on naproxen measurement, the blood serum sample was prepared, and after addition of a known concentration of standard solution of naproxen, the amount of the percentage recovery was obtained by the DPV method (Table 5). The results in Tables 4 and 5 show that their complicated compound of tablet, blood serum, and real samples did not have any effect on the efficacy of naproxen.

Concentration of naproxen labeled	Naproxen added (μM)	Naproxen found (μM)	Recovery (%)
250 mg	–	4.98 ± 0.9	99.8
30	34.88 ± 1.2	99.7
60	64.83 ± 1.3	99.7
90	94.82 ± 1.4	99.8
500 mg	–	9.98 ± 1.1	99.8
20	29.95 ± 1.3	99.8
40	49.84 ± 1.4	99.7
60	69.79 ± 1.5	99.7

Human serum	Naproxen added (μM)	Naproxen found (μM)	Recovery (%)	RSD (%)
Sample 1	20	19.8 ± 1.2	99.0	1.1
Sample 2	40	39.5 ± 1.3	98.8	1.3
Sample 3	60	59.2 ± 1.3	98.7	1.3
Sample 4	80	78.8 ± 1.4	98.5	1.4
Sample 4	100	98.7 ± 1.2	98.7	1.4

3.10 Determination of naproxen in the presence of acetaminophen

As mentioned in Section 1, one of the goals of this study was to determine naproxen in the presence of acetaminophen. For this purpose, in the first stage, the concentration of acetaminophen was kept 150 μM, and naproxen concentration was changed from 25 to 130 μM. In the second stage, the concentration of acetaminophen was changed from 35 to 190 μM, whereas that of naproxen was fixed in 50 μM. According to DPVs in Fig. 7, the peak current of acetaminophen remains constant when the concentration of naproxen is changed, and a linear relationship between the concentration and peak current of naproxen can be observed. Similar conclusions were obtained for the second stage. These results demonstrate that measuring these two drugs together by using the modified electrode is possible. Therefore, in the biological samples where these two drugs exist, this electrode may be useful for their simultaneous determination.

Fig. 7
DPV of different concentrations of (a) naproxen (35, 45, 65, 80, 95, 100, and 130 μM) in the presence of 150 μM of acetaminophen and (b) acetaminophen (35, 65, 80, 100, 140, and 190 μM) in the presence of 50 μM of naproxen.

4 Conclusions

In this study, the electrochemical behavior of the modified CPE by ACNPs in the oxidation process of naproxen was investigated. Addition of ACNPs to CPE increased the peak current of naproxen up to 4.5 times due to its high electrical conductivity and high specific surface area. The detection limit for naproxen drug using the modified CPE was 0.0234 μM. The linear relationship between the peak current and the square root of potential showed that the oxidation of naproxen was controlled by mass transfer and the species penetration to the electrode for the oxidation. The selectivity of this method was achieved by investigating the effect of interferences. This method was demonstrated by pharmaceutical and real samples showing that it did not have any significant difference from the standard method. Moreover, this method was stable, available, fast, simple, economical, and precise.

Acknowledgments

The financial support of the research council of Payame Noor University of Isfahan is gratefully acknowledged.

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Artur Jędrzak; Teofil Jesionowski Enhanced 3D-printed Matrix for Electrocatalytic Detection: A Practical and Simple Electrochemical Platform, Electrocatalysis, Volume 16 (2025) no. 1, p. 141 | DOI:10.1007/s12678-024-00910-w
N. Soltani; N. Tavakkoli; E. Eslami; L.S. Mirmohammadi Electrochemical measurement of naproxen in the presence of diclofenac and ascorbic acid using Gr/ZnFe2O4/CPE, Diamond and Related Materials, Volume 141 (2024), p. 110569 | DOI:10.1016/j.diamond.2023.110569
Rufina A. Zilberg; Julia B. Teres; Elena O. Bulysheva; Ivan V. Vakulin; Genghiskhan R. Mukhametdinov; Olga V. Khromova; Maria V. Panova; Michael G. Medvedev; Victor I. Maleev; Vladimir A. Larionov Chiral octahedral cobalt(III) complex immobilized on Carboblack C as a novel robust and readily available enantioselective voltammetric sensor for the recognition of tryptophan enantiomers in real samples, Electrochimica Acta, Volume 492 (2024), p. 144334 | DOI:10.1016/j.electacta.2024.144334
J. Molina; L. Olcina; J. Bonastre; F. Cases Naproxen electrooxidation using carbon paper electrodes modified with reduced graphene oxide and platinum nanoparticles, Journal of Electroanalytical Chemistry, Volume 967 (2024), p. 118454 | DOI:10.1016/j.jelechem.2024.118454
Nguyen Le My Linh; Dang Thi Thanh Nhan; Dinh Quy Huong; Do Mai Nguyen; Nguyen Thi Thao Uyen; Doan Manh Dung; Trinh Ngoc Dat; Le Van Thanh Son; Tran Thanh Tam Toan; Dinh Quang Khieu Simultaneous determination of uric acid and xanthine in human urine using differential pulse voltammetry with ZnMn2O4 modified electrode, Journal of Nanoparticle Research, Volume 26 (2024) no. 5 | DOI:10.1007/s11051-024-06018-y
Ebrahim Zarei; Mohammad Reza Khaleghi; Alireza Asghari Development of ZnO-Pd/Bi2O3 nanocomposite modified carbon paste electrode as a sensor for the simultaneous determination of piroxicam and naproxen, Microchemical Journal, Volume 207 (2024), p. 111924 | DOI:10.1016/j.microc.2024.111924
Engin Seker Effect of naproxen on oxidative stress biomarkers in Gammarus pulex, Revista Científica de la Facultad de Ciencias Veterinarias, Volume XXXIV (2024) no. 3, p. 1 | DOI:10.52973/rcfcv-e34505
David Aurelio-Soria; Xochitl H. Canales; Isai Vázquez-Garrido; Gabriela Islas; Giaan A. Álvarez-Romero; Israel S. Ibarra Design of Selective Nanoparticles of Layered Double Hydroxide (Mg/Al-LDH) for the Analysis of Anti-Inflammatory Non-Steroidal Agents in Environmental Samples, Coupled with Solid-Phase Extraction and Capillary Electrophoresis, Separations, Volume 11 (2024) no. 9, p. 259 | DOI:10.3390/separations11090259
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Chang-Mao Hung; Chin-Pao Huang; Chiu-Wen Chen; Cheng-Di Dong A poly-(L-serine)/reduced graphene oxide–Nafion supported on glassy carbon (PLS/rGO−Nafion/GCE) electrode for the detection of naproxen in aqueous solutions, Environmental Science and Pollution Research, Volume 29 (2022) no. 9, p. 12450 | DOI:10.1007/s11356-021-15511-z
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Md. Shalauddin; Shamima Akhter; Wan Jefrey Basirun; Nadzirah Sofia Anuar; Omid Akbarzadeh; Mohammed Alhaji Mohammed; Mohammad Rafie Johan Carboxylated nanocellulose dispersed nitrogen doped graphene nanosheets and sodium dodecyl sulfate modified electrochemical sensor for the simultaneous determination of paracetamol and naproxen sodium, Measurement, Volume 194 (2022), p. 110961 | DOI:10.1016/j.measurement.2022.110961
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Ana Paula Rizzato Nakamura; Daniela Silvestrini Fernandes; Eduardo Guimarães Vieira; Newton Luis Dias Filho; Devaney Ribeiro do Carmo Voltammetric Detection of Nitrite Throught a Chemically Modified (5-Amino-1,3,4-Thiadiazolyl-2-Thiol) Propyl Silica Gel, Silicon, Volume 13 (2021) no. 1, p. 221 | DOI:10.1007/s12633-020-00417-1
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Thiago M. do Prado; Carolina C. Badaró; Rafaela G. Machado; Pedro S. Fadini; Orlando Fatibello‐Filho; Fernando C. Moraes Using Bismuth Vanadate/Copper Oxide Nanocomposite as Photoelectrochemical Sensor for Naproxen Determination in Sewage, Electroanalysis, Volume 32 (2020) no. 9, p. 1930 | DOI:10.1002/elan.202000055
Peyman Mohammadzadeh Jahani; Hamid Akbari Javar; Hadi Mahmoudi-Moghaddam Development of a novel electrochemical sensor using the FeNi3/CuS/BiOCl nanocomposite for determination of naproxen, Journal of Materials Science: Materials in Electronics, Volume 31 (2020) no. 17, p. 14022 | DOI:10.1007/s10854-020-03876-9
Seyedeh-Fatemeh Mousavi; Mohammad Alimoradi; Abbas Shirmardi; Vahid Zare-Shahabadi Preparation, characterization and electrochemical application of an Ag/zeolite nanocomposite: application to sub-micromolar quantitation of tryptophan, Journal of Porous Materials, Volume 27 (2020) no. 5, p. 1505 | DOI:10.1007/s10934-020-00928-7
G. Y. Aguilar-Lira; A. Rojas-Hernández; J. A. Rodriguez; M. E. Páez-Hernández; G. A. Álvarez-Romero Optimized Quantification of Naproxen Based on DPV and a Multiwalled MWCNT-Carbon Paste Electrode, Journal of The Electrochemical Society, Volume 167 (2020) no. 16, p. 166510 | DOI:10.1149/1945-7111/abd04c
Dhouha Jemmeli; Chadlia Mchiri; Chérif Dridi; Habib Nasri; Eithne Dempsey Development of a new bisphenol A electrochemical sensor based on a cadmium(ii) porphyrin modified carbon paste electrode, RSC Advances, Volume 10 (2020) no. 53, p. 31740 | DOI:10.1039/d0ra04793g
Maryam Shirinnejad; Amir H. M. Sarrafi Dispersive Liquid-Liquid Microextraction Based on Solidification of Floating Organic Drop with Central Composite Design for the Spectrofluorometric Determination of Naproxen, Journal of Fluorescence, Volume 29 (2019) no. 4, p. 1039 | DOI:10.1007/s10895-019-02417-w
Elham Asadian; Masoumeh Ghalkhani; Saeed Shahrokhian Electrochemical sensing based on carbon nanoparticles: A review, Sensors and Actuators B: Chemical, Volume 293 (2019), p. 183 | DOI:10.1016/j.snb.2019.04.075
Eva Díaz; Sonia Stożek; Yolanda Patiño; Salvador Ordóñez Electrochemical degradation of naproxen from water by anodic oxidation with multiwall carbon nanotubes glassy carbon electrode, Water Science and Technology, Volume 79 (2019) no. 3, p. 480 | DOI:10.2166/wst.2019.070
Katarzyna Krukiewicz; Aleksandra Kruk; Roman Turczyn Evaluation of drug loading capacity and release characteristics of PEDOT/naproxen system: Effect of doping ions, Electrochimica Acta, Volume 289 (2018), p. 218 | DOI:10.1016/j.electacta.2018.09.011
Mir Hilal Ahmad; Mahino Fatima; Mobarak Hossain; Amal Chandra Mondal Evaluation of naproxen-induced oxidative stress, hepatotoxicity and in-vivo genotoxicity in male Wistar rats, Journal of Pharmaceutical Analysis, Volume 8 (2018) no. 6, p. 400 | DOI:10.1016/j.jpha.2018.04.002

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