Comptes Rendus
no. 3
Transfer of para-hydrogen spin order into polarization by diabatic field cycling
[Transfert de cohérence de spin de para hydrogène à polarisation par changement diabatique du champ magnétique]

Présenté par : Guy Laval

Haukur Jóhannesson1  ; Oskar Axelsson1  ; Magnus Karlsson1
1 Amersham Health R&D AB, Medeon, 205 12 Malmö, Sweden
Comptes Rendus. Physique, Volume 5 (2004) no. 3, pp. 315-324.

Dans une expérience de polarisation induite par para hydrogène (PHIP), il est possible d'obtenir une polarisation substantielle sur un hétéronoyau par l'utilisation d'une technique de changement diabatique du champ magnétique. Cela est démontré expérimentalement dans le cas du propionate d'hydroxyethyle. Le champ ambiant est réduit avec plusieurs cylindres concentriques de mu-métal. La variation du champ magnétique est modélisée comme une transition abrupte d'un champ intermédiaire vers un champ très faible suivie par une réaimantation adiabatique. Une expression analytique de la polarisation en fonction des couplages scalaires est dérivée pour un système de spins AA′X en considérant un profil de champ magnétique idéalisé. Il est aussi démontré que l'entitée hyperpolarisée peut être utilisée pour l'imagerie par résonance magnétique (IRM).

In a para-hydrogen induced polarization (PHIP) experiment, it is possible to obtain a substantial net polarization of a hetero nucleus using a diabatic field cycling scheme. This is experimentally demonstrated for hydroxyethyl propionate. The screening of the ambient magnetic field was accomplished by using several concentric mu-metal cylinders. The field cycling is modeled as a sudden decrease from intermediate field to low field, followed by an adiabatic remagnetization. An analytical expression for the polarization as a function of the constituent scalar couplings, using an idealized field cycling profile, is derived for an AA′X spin system. It is also demonstrated that the hyperpolarized compound can be used for magnetic resonance imaging (MRI).

Publié le :
DOI : 10.1016/j.crhy.2004.02.001
Keywords: Para-hydrogen induced polarization, Diabatic, Field cycling
Mot clés : Polarisation induite par para hydrogène, diabatique, champ magnétique cyclé
Haukur Jóhannesson 1 ; Oskar Axelsson 1 ; Magnus Karlsson 1

1 Amersham Health R&D AB, Medeon, 205 12 Malmö, Sweden 
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Haukur Jóhannesson; Oskar Axelsson; Magnus Karlsson. Transfer of para-hydrogen spin order into polarization by diabatic field cycling. Comptes Rendus. Physique, Volume 5 (2004) no. 3, pp. 315-324. doi : 10.1016/j.crhy.2004.02.001. https://comptes-rendus.academie-sciences.fr/physique/articles/10.1016/j.crhy.2004.02.001/

[1] C.R. Bowers; D.P. Weitekamp Transformation of symmetrization order to nuclear-spin magnetization by chemical reaction and nuclear magnetic resonance, Phys. Rev. Lett., Volume 57 (1986), pp. 2645-2648

[2] C.R. Bowers; D.P. Weitekamp Parahydrogen and synthesis allow dramatically enhanced nuclear alignment, J. Am. Chem. Soc., Volume 109 (1987), pp. 5541-5542

[3] M.G. Pravica; D.P. Weitekamp Net NMR alignment by adiabatic transport of parahydrogen addition products to high magnetic field, Chem. Phys. Lett., Volume 145 (1988) no. 4, pp. 255-258

[4] G. Buntkowsky; J. Bargon; H.-H. Limbach A dynamic model of reaction pathway effects on parahydrogen-induced nuclear spin polarization, J. Am. Chem. Soc., Volume 118 (1996), pp. 8677-8683

[5] T.C. Eisenschmid; J. McDonald; R. Eisenberg INEPT in a chemical way. Polarization transfer from parahydrogen to 31P by oxidative addition and dipolar relaxation, J. Am. Chem. Soc., Volume 111 (1989), pp. 7267-7269

[6] R. Eisenberg; T.C. Eisenschmid; M.S. Chinn; R.U. Kirss Parahydrogen-induced polarization and polarization transfer in hydrogenation and oxidative addition reactions, Adv. Chem., Volume 230 (1992), pp. 47-74

[7] J. Barkemeyer; M. Haake; J. Bargon Hetero-NMR enhancement via parahydrogen labeling, J. Am. Chem. Soc., Volume 117 (1995), pp. 2927-2928

[8] J. Natterer; O. Schedletzky; J. Barkemeyer; J. Bargon; S.J. Glaser Investigating catalytic processes with parahydrogen: evolution of zero-quantum coherence in AA′X spin systems, J. Magn. Reson., Volume 133 (1998), pp. 92-97

[9] J. Barkemeyer; J. Bargon; H. Sengstschmid; R. Freeman Heteronuclear polarization transfer using selective pulses during hydrogenation with parahydrogen, J. Magn. Reson. Ser. A, Volume 120 (1996), pp. 129-132

[10] M. Haake; J. Natterer; J. Bargon Efficient NMR pulse sequence to transfer the parahydrogen-induced polarization to hetero nuclei, J. Am. Chem. Soc., Volume 118 (1996), pp. 8688-8691

[11] K. Golman; O. Axelsson; H. Jóhannesson; S. Månsson; C. Olofsson; J.S. Petersson Parahydrogen-induced polarization in imaging: subsecond 13C angiography, Magn. Reson. Med., Volume 46 (2001), pp. 1-5

[12] C.R. Bowers Sensitivity enhancement utilizing parahydrogen (D.M. Grant; R.K. Harris, eds.), Encyclopedia of Nuclear Magnetic Resonance, vol. 9, Wiley, Chichester, 2002

[13] L.D. Landau; E.M. Lifshitz, Quantum Mechanics (Non-Relativistic Theory) Course of Theoretical Physics, vol. 3, Butterworth–Heinemann, Oxford, 1998

[14] D.A. McQuarrie Statistical Mechanics, Harper Collins, New York, 1976

[15] A. Oppelt; R. Graumann; H. Barfuss; H. Fischer; W. Hartl; W. Schajor FISP-a new fast MRI sequence, Electromedica, Volume 54 (1986), pp. 15-18

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