New routes to carbene complexes for thermally and oxidatively robust homogeneous catalysts

Eduardo Peris; Robert H. Crabtree

doi:10.1016/S1631-0748(03)00003-1

Account / Revue

New routes to carbene complexes for thermally and oxidatively robust homogeneous catalysts

Eduardo Peris ¹ ; Robert H. Crabtree ²

¹ Universitat Jaume I, 12080 Castellon, Spain
² Yale Chemistry Department, New Haven, CT, 06520-8107, USA

Comptes Rendus. Chimie, Volume 6 (2003) no. 1, pp. 33-37.

Résumés

Anglais
Français

Two synthetic methods allow synthesis of catalytically active metal carbene complexes from imidazolium salts without passing through the free carbene. Abnormal carbene binding via C-4(5) is possible, influenced by ion pairing. Imidazolium-based ionic liquids may be non-innocent solvents in homogeneous catalysis.

Des complexes carbéniques issus de sels d’imidazolium sont synthétisés par deux voies, sans passer par le carbène libre, et peuvent être utiles en catalyse homogène. De tels carbènes peuvent également se lier anormalement en C-4(5), selon le contre-ion. On avance l’hypothèse que des liquides ioniques peuvent potentiellement jouer le rôle de ligands en catalyse homogène.

Métadonnées

Reçu le : 2002-06-22
Accepté le : 2002-10-10
Publié le : 2003-01-01

DOI : 10.1016/S1631-0748(03)00003-1

Keywords: metal carbene complexes, imidazolium salts, free carbene, ion pairing, ionic liquids, homogeneous catalysis
Mots-clés : complexes carbéniques, sels d’imidazolium, carbène libre, paires d’ions, liquides ioniques, catalyse homogène

Affiliations des auteurs :

Eduardo Peris ¹ ; Robert H. Crabtree ²

¹ Universitat Jaume I, 12080 Castellon, Spain
² Yale Chemistry Department, New Haven, CT, 06520-8107, USA

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Eduardo Peris; Robert H. Crabtree. New routes to carbene complexes for thermally and oxidatively robust homogeneous catalysts. Comptes Rendus. Chimie, Volume 6 (2003) no. 1, pp. 33-37. doi : 10.1016/S1631-0748(03)00003-1. https://comptes-rendus.academie-sciences.fr/chimie/articles/10.1016/S1631-0748(03)00003-1/

Version originale du texte intégral

Le texte intégral ci-dessous peut contenir quelques erreurs de conversion par rapport à la version officielle de l'article publié.

1 Introduction

The concept of forming N-heterocyclic carbene (NHC) complexes by replacing the acidic 2-H of the imidazole ring by a metal fragment dates back to the work of Öfele and of Lappert [1] (Fig. 1). The area remained quiescent for decades until Arduengo [2] showed that the free carbene could be obtained as a species stable enough for crystallographic characterization if sufficiently bulky alkyl or aryl groups were present at the 1 and 3 positions. Herrmann [3] took the story a step further by showing that such carbenes are excellent stabilizing ligands for a variety of homogeneous catalysts. Tens of research groups [4a] have added carbenes to their armory and have provided further examples of catalysts for a wide variety of reactions. Among organometallic catalysts, only phosphines are currently more versatile than carbenes and since the carbene field is much less developed, we can expect rapid advance in the next few years. We have also recently reviewed related aspects of our work in the field [4b].

2 Base-assisted metallations

Our efforts have been directed towards incorporating NHCs into chelate [5] and pincer [6] ligand systems such as have proved invaluable in phosphine-based catalysis. This requires us to avoid the standard synthetic route [4] via deprotonation at the imidazole 2-position because this requires strong bases and nucleophiles. These are likely to prove incompatible with the types of poly-imidazolium salts that are needed to gain access to chelate and pincer NHCs because these can contain a variety of acidic and electrophilic centers that would lead to mixtures of products. In addition, we wanted to be able to use smaller wingtip groups at 1 and 3 positions than are required to stabilize the free carbenes.

Agostic C–H binding to metals [7] is known to acidify the proton that is bound, leading to the idea that a metal acetate might be able to give direct metallation via the reaction of equation (1). In this scheme, the oxidation state of the final product is expected to be the same as that of the starting acetate. As a test of this procedure for a CNC pincer carbene complex, we looked at the reaction of equation (1), in which the readily prepared bis-imidazolium salt, 1, reacts with Pd(OAc)₂ at 165 °C to give the square planar Pd(II) complex, 2 [8]. The complex is unaffected by heating for many days at 165 °C in DMSO and air, in contrast with phosphine derivatives which tend to decompose at this temperature even in the absence of air. Note the use of the pyridine unit to act as the initial binding site for the ligand, bringing the imidazolium rings into the vicinity of the metal.

The robustness of 2 is demonstrated by its ability to catalyze the Heck reaction at 165 °C, even in air. We checked that the system retained activity in the presence of Hg(0), suggesting that metallic Pd(0) is not the catalytically active species. The related Sonogashira and Suzuki coupling reactions are also catalyzed by 2 [8].

The high stability of 2 prompted a study of its immobilization in a clay to look at the catalytic activity of the heterogeneized system [9]. Indeed, 2 and related compounds with different wingtip alkyl groups (n-Bu, CH₂Ph, etc.) can readily be immobilized by impregnation on montmorillonite K-10, affording effective supported catalysts for the standard Heck coupling. The supported catalysts so obtained show catalytic activity similar to that of their homogeneous counterparts. The determination of Pd content on the supported catalysts by XPS and elemental analysis, before and after each catalytic reaction, shows that leaching is negligible. The XPS analysis of the catalysts after its use in the catalytic reactions showed that no Pd(0) is produced. Once the reaction conditions were optimized, we were able to recycle the catalyst at least ten times, without significant loss of activity, even in the cases where the reactions were performed at 180 °C.

The methylene-linked CNC pincer, 3 [10], is also readily metallated in a similar manner to give a twisted pincer complex, 4, with a chiral conformation (equation (2)). Ready conversion between the two chiral atropisomers is possible on the NMR timescale, so the complexes cannot be used for the asymmetric version of the Heck reaction. It should be possible to block the interconversion by replacing a linker proton with an alkyl or aryl group, however, in which case the wingtip R groups would project in a chiral manner into the substrate binding pocket.

3 Metallation via CH activation

Such a CH activation has been demonstrated for Pt(0) [11] and is suspected for Pd(0) [12]. Another indication of the viability of CH activation as a synthetic route, came from our synthesis of the CCC pincer analogue, 6, from precursor 5. In this case, a C–Br oxidative addition was chosen to install the phenylene group in analogy with the pyridine group of the CNC pincer. As the oxidative addition was expected to require a low-oxidation-state starting material, we turned to the common Pd(0) complex, Pd₂dba₃. The final product contained a bis-carbene product with no indication of the monocarbene intermediate (equation (3)). This route was efficient under air or argon, so H₂ may be released in the reaction.

This proposal of H₂ release was followed up by looking at the reaction of the mono-imidazolium salts, 7, with Pd₂dba₃ [13]. Instead of the formation of a carbene Pd(II) hydride, only the bis carbene was isolated or observed even with restricted amounts of imidazolium salt and under mild conditions (equation (4)). This makes it seem that the second step of the reaction, between a metal hydride and an imidazolium salt, can be very fast, even though intermolecular. This suggested that a general route to carbene complexes might be possible by reaction of a metal hydride with an imidazolium salt.

We were therefore encouraged to look for other examples of the proposed pathway of equation (4) [14]. Since IrH₅L₂ (L = PPh₃) is known to react with pyridine in THF at reflux to give [Ir(py)H₃L₂], we looked at the pyridine–carbene chelate precursor, 8. This indeed reacts with IrH₅L₂, but to give the abnormal ‘wrong way’ product 9, in which the metal is attached, not to the activated C-2 position, but to C-5 (equation (5)). This was obvious both from the X-ray structure and from the spectroscopic data.

On moving to the smaller wingtip Me group, we were able to obtain a 55:45 ratio of the wrong and right carbenes (equation (6)). Later work described below yielded the pure right (C-2) and wrong (C-5) carbenes for study. One well-marked spectroscopic difference between the two was the chemical shift difference between the two imidazolium protons in the two isomers. In the normal carbene, these are little different and, accordingly, are little apart from one another in the NMR spectrum. In the abnormal form, in contrast, the two Hs differ substantially, one being the active 2-H and the other being the C-5 H endo to the metal. These differ by a full 2–4 ppm in chemical shift. The mechanism of the formation of the C-4(5) bound NHC is still uncertain and needs further study.

This work established the existence of 4(5)-bound carbene complexes, where the electronic situation is presumably closer to that in the more normal Fischer carbenes of type L_nMCR(NR₂). It also implies that catalysts that are formed in situ by incubation of a metal salt with an imidazolium ion may not have the expected structure. Abnormal binding may be generally expected for hydride precursors but we find it can be suppressed by blocking the 4,5 sites, for example using the benzimidazolium analogues.

A remarkably strong anion effect was seen in this system: the BF₄^– imidazolium salt gave the 55:45 mixture of isomers mentioned above, but Br^– as counter-ion gave essentially only the C-2 product and SbF₆^– gave essentially only the C-4(5) form. Such a large shift from one product to another is unexpected and probably related to the existence of tight ion pairs for organometallic ions in solution in solvents such as CH₂Cl₂ or THF. Theoretical work by Clot and Eisenstein [15] on the system showed that while the free carbene and the Ir complex favor binding at C-2, inclusion of the counter-ion in the calculation (DFT) led to an essentially isoenergetic situation. Attempts to interconvert the isomers completely failed, so these are kinetic not thermodynamic products, but the same ion-pairing effects presumably operate at the relevant transition states.

The ion-pair structure was directly observed in a prior case in NMR using NOE effects and the experimentally favored ion-pair structure was predicted from DFT calculations of the electric field around the cation [16]. In the present case, ion pairing was readily apparent because the C-2 proton of the C-4(5) carbene, pointing to the exterior of the molecule, shifts by about 2 ppm on addition of Br-ion to the SbF₆ salt but no other resonance is much affected. Together with the C-H···anion hydrogen bonding seen in the X-ray structure, this illustrates the special affinity of the C-4(5) carbene for the anion, stabilizing this form relative to the C-2 one.

This result illustrates the potential importance of the counter-ion, often ignored in organometallic work to the extent of omitting it from the diagram of the complex reported in the paper. This attitude commonly leads to work being carried out with only one counter-ion in which case counter-ion effects would be missed. Ion pairing has been implicated in metallocene polymerization, however [17]. A change of anion has sometimes proved beneficial in improving the ee of asymmetric catalytic reactions with late transition metals [18].

Our initial work in catalytic rhodium [19] and iridium chemistry is illustrated in equation (7) where the bidentate carbene precursor salt has no initial binding site such as the pyridine of the CNC pincer. In spite of this, the synthesis of the product occurs in good or acceptable yield. The Rh(III) product has rather poor catalytic activity but the Ir(III) species can be very active for transfer hydrogenation from iPrOH as solvent to Ph₂CO, with up to 50 000 turnovers per hour at 80° C (M = Ir; Ph₂CO/cata/base: 1000/1/5) in the presence or absence of air. By far the best wingtip group in this chemistry is neopentyl. This could be preferred because it lacks β-hydrogens, which exempts it from Hoffmann degradation of the wingtip alkyls, but benzyl that also lacks β-Hs is poor.

Neopentyl groups seem to improve the synthetic yields as well as giving highly active catalysts, so we have continued to use them. The weak link in the bis-carbene is probably the central CH₂ group that we hope to replace by a more inert linker in future work. Again the catalyst system is entirely unaffected by air and is very robust compared to comparable phosphine systems. The tolerance of what are usually catalyst poisons such as air and water could make these catalysts more generally useful than phosphine analogues and hold hope for future developments. Such catalysts could also be regarded as at least somewhat ‘green’ in avoiding the presence of phosphorus and in not needing inert atmosphere or dry conditions, provision of which imply energy input.

4 Non-innocence of imidazolium derived ionic liquids as solvents

The ready metallation of the imidazolium salts under a variety of conditions raises another point relevant to green chemistry. Ionic liquids commonly used in that field as solvents for TM catalysts are very often imidazolium salts [20]. It is therefore obvious that carbene complexes could well be formed in situ under reaction conditions in which case the ionic liquid could play more than a purely solvent role; an example of such a situation has indeed just been reported [21].

5 C-Bound histidine in metalloenzymes

Since metals are often bound via histidine (His) in metalloenzymes, but X-ray structural studies of the protein cannot distinguish between C and N, it is possible that His may be capable of binding in a non-classical C-form [22]. If so, organometallic species could be far more common in biology than currently recognized. In collaboration with Sini and Eisenstein [23], we looked at this problem by calculating the energy difference expected between C and N bound forms of imidazole. The results showed that for many metal fragments the C-bound form was predicted to be thermodynamically more stable. The better hydrogen bonding possible by the NH bonds at positions 1 and 3 in the C-bound form, versus a single such bond in the N-bound form may help stabilize the C-His form. A metalloenzyme could readilyarrange the presence of suitable hydrogen bond bases to favor the C-form. The N to C rearrangement might be expected to have a significant barrier, but in a single case Taube [24] experimentally observed such a rearrangement at room temperature, so the barrier need not be excessive. No cases are yet known in enzymes, however, but it is hard to tell C from N binding. A recent review has reiterated this proposal [3b].

6 Outlook

The strong binding, thermal stability and air stability of carbene complexes mean that they have substantial advantages over other ligand types. The easy incorporation of imidazolium and related heterocycles such as triazoliums into complex architectures suggests that they may prove useful in a variety of materials and sensor applications or in situations where a molecular recognition element or cooperative reactive function is appended to a catalytic site. Their oxidative robustness should allow catalysis of oxidation reactions, previously difficult in view of the oxidation of PR₃ complexes.

7 Conclusions

Synthetic routes that avoid strong bases allow N-heterocyclic carbenes to be incorporated into pincer and chelate ligands that can give catalysts that are very thermally robust and are catalytically active even in air. Binding at C-5 is observed in some cases depending on the nature of the counter-ion. Neopentyl wingtip groups prove to be particularly useful. The possibilityof C-bound histidine in metalloenzymes is discussed.

Acknowledgements

We thank Odile Eisenstein, Éric Clot and Gjergji Sini for their very valuable collaboration on theoretical aspects of the work, and the DOE for funding.

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Alessandro Zanardi; Eduardo Peris; Jose A. Mata Alkenyl-functionalized NHC iridium-based catalysts for hydrosilylation, New J. Chem., Volume 32 (2008) no. 1, p. 120 | DOI:10.1039/b707280e
Alessandro Zanardi; Rosa Corberán; José A. Mata; Eduardo Peris Homo- and Heterodinuclear Complexes with Triazolyl-diylidene. An Easy Approach to Tandem Catalysts, Organometallics, Volume 27 (2008) no. 14, p. 3570 | DOI:10.1021/om800411v
Amparo Prades; Mónica Viciano; Mercedes Sanaú; Eduardo Peris Preparation of a Series of “Ru(p-cymene)” Complexes with Different N-Heterocyclic Carbene Ligands for the Catalytic β-Alkylation of Secondary Alcohols and Dimerization of Phenylacetylene, Organometallics, Volume 27 (2008) no. 16, p. 4254 | DOI:10.1021/om800377m
André Pontes da Costa; Mónica Viciano; Mercedes Sanaú; Sonia Merino; Juan Tejeda; Eduardo Peris; Beatriz Royo First Cp*-Functionalized N-Heterocyclic Carbene and Its Coordination to Iridium. Study of the Catalytic Properties, Organometallics, Volume 27 (2008) no. 6, p. 1305 | DOI:10.1021/om701186u
Macarena Poyatos; William McNamara; Chris Incarvito; Eric Clot; Eduardo Peris; Robert H. Crabtree A Weak Donor, Planar Chelating Bitriazole N-Heterocyclic Carbene Ligand for Ruthenium(II), Palladium(II), and Rhodium, Organometallics, Volume 27 (2008) no. 9, p. 2128 | DOI:10.1021/om800021c
Elena Mas‐Marzá; José A. Mata; Eduardo Peris Triazolediylidenes: A Versatile Class of Ligands for the Preparation of Discrete Molecules of Homo‐ and Hetero‐Binuclear Complexes for Improved Catalytic Applications, Angewandte Chemie, Volume 119 (2007) no. 20, p. 3803 | DOI:10.1002/ange.200700535
Elena Mas‐Marzá; José A. Mata; Eduardo Peris Triazolediylidenes: A Versatile Class of Ligands for the Preparation of Discrete Molecules of Homo‐ and Hetero‐Binuclear Complexes for Improved Catalytic Applications, Angewandte Chemie International Edition, Volume 46 (2007) no. 20, p. 3729 | DOI:10.1002/anie.200700535
Vanesa Lillo; Jose A. Mata; Anna M. Segarra; Eduardo Peris; Elena Fernandez The active role of NHC ligands in platinum-mediated tandem hydroboration–cross coupling reactions, Chem. Commun. (2007) no. 21, p. 2184 | DOI:10.1039/b700800g
José A. Mata; Macarena Poyatos; Eduardo Peris Structural and catalytic properties of chelating bis- and tris-N-heterocyclic carbenes, Coordination Chemistry Reviews, Volume 251 (2007) no. 5-6, p. 841 | DOI:10.1016/j.ccr.2006.06.008
Fritz E. Kühn; Alexandrina D. Tanase; Eberhardt Herdtweck; Wolfgang A. Herrmann A Palladium(II) Complex Containing Imidazole Moieties. Synthesis and Structural Examination, HETEROCYCLES, Volume 73 (2007) no. 1, p. 651 | DOI:10.3987/com-07-s(u)44
Eduardo Peris; Robert H. Crabtree ‘Pincer’-carbene complexes, The Chemistry of Pincer Compounds (2007), p. 107 | DOI:10.1016/b978-044453138-4/50007-6
Elena Mas-Marzá; Patrícia M. Reis; Eduardo Peris; Beatriz Royo Dioxomolybdenum(VI) complexes containing N-heterocyclic carbenes, Journal of Organometallic Chemistry, Volume 691 (2006) no. 12, p. 2708 | DOI:10.1016/j.jorganchem.2006.02.004
Eduardo Peris Routes to N-Heterocyclic Carbene Complexes, N-Heterocyclic Carbenes in Transition Metal Catalysis, Volume 21 (2006), p. 83 | DOI:10.1007/978-3-540-36930-1_4
Mónica Viciano; Elena Mas-Marzá; Mercedes Sanaú; Eduardo Peris Synthesis and Reactivity of New Complexes of Rhodium and Iridium with Bis(dichloroimidazolylidene) Ligands. Electronic and Catalytic Implications of the Introduction of the Chloro Substituents in the NHC Rings, Organometallics, Volume 25 (2006) no. 12, p. 3063 | DOI:10.1021/om060174a
Cristian Vicent; Mónica Viciano; Elena Mas-Marzá; Mercedes Sanaú; Eduardo Peris Electrospray Ionization Mass Spectrometry Studies on the Mechanism of Hydrosilylation of Terminal Alkynes Using an N-Heterocyclic Carbene Complex of Iridium, Allow Detection/Characterization of All Reaction Intermediates, Organometallics, Volume 25 (2006) no. 15, p. 3713 | DOI:10.1021/om0602308
Vanesa Lillo; Jose Mata; Jesús Ramírez; Eduardo Peris; Elena Fernandez Catalytic Diboration of Unsaturated Molecules with Platinum(0)−NHC: Selective Synthesis of 1,2-Dihydroxysulfones, Organometallics, Volume 25 (2006) no. 24, p. 5829 | DOI:10.1021/om060666n
Mónica Viciano; Macarena Poyatos; Mercedes Sanaú; Eduardo Peris; Andrea Rossin; Gregori Ujaque; Agustí Lledós C−H Oxidative Addition of Bisimidazolium Salts to Iridium and Rhodium Complexes, and N-Heterocyclic Carbene Generation. A Combined Experimental and Theoretical Study, Organometallics, Volume 25 (2006) no. 5, p. 1120 | DOI:10.1021/om051004l
Rosa Corberán; Jesus Ramírez; Macarena Poyatos; Eduardo Peris; Elena Fernández Coinage metal complexes with N-heterocyclic carbene ligands as selective catalysts in diboration reaction, Tetrahedron: Asymmetry, Volume 17 (2006) no. 12, p. 1759 | DOI:10.1016/j.tetasy.2006.06.027
David Martin; Antoine Baceiredo; Heinz Gornitzka; Wolfgang W. Schoeller; Guy Bertrand A Stable P‐Heterocyclic Carbene, Angewandte Chemie, Volume 117 (2005) no. 11, p. 1728 | DOI:10.1002/ange.200462239
Mónica Viciano; Elena Mas‐Marzá; Macarena Poyatos; Mercedes Sanaú; Robert H. Crabtree; Eduardo Peris An N‐Heterocyclic Carbene/Iridium Hydride Complex from the Oxidative Addition of a Ferrocenyl–Bisimidazolium Salt: Implications for Synthesis, Angewandte Chemie, Volume 117 (2005) no. 3, p. 448 | DOI:10.1002/ange.200461918
David Martin; Antoine Baceiredo; Heinz Gornitzka; Wolfgang W. Schoeller; Guy Bertrand A Stable P‐Heterocyclic Carbene, Angewandte Chemie International Edition, Volume 44 (2005) no. 11, p. 1700 | DOI:10.1002/anie.200462239
Mónica Viciano; Elena Mas‐Marzá; Macarena Poyatos; Mercedes Sanaú; Robert H. Crabtree; Eduardo Peris An N‐Heterocyclic Carbene/Iridium Hydride Complex from the Oxidative Addition of a Ferrocenyl–Bisimidazolium Salt: Implications for Synthesis, Angewandte Chemie International Edition, Volume 44 (2005) no. 3, p. 444 | DOI:10.1002/anie.200461918
Ivan JB Lin; Chandra Sekhar Vasam Review of gold(I) N-heterocyclic carbenes, Canadian Journal of Chemistry, Volume 83 (2005) no. 6-7, p. 812 | DOI:10.1139/v05-087
Jesus Ramírez; Rosa Corberán; Mercedes Sanaú; Eduardo Peris; Elena Fernandez Unprecedented use of silver(i) N-heterocyclic carbene complexes for the catalytic preparation of 1,2-bis(boronate) esters, Chemical Communications (2005) no. 24, p. 3056 | DOI:10.1039/b503239c
Elena Mas-Marzá; Mercedes Sanaú; Eduardo Peris Coordination Versatility of Pyridine-Functionalized N-Heterocyclic Carbenes: A Detailed Study of the Different Activation Procedures. Characterization of New Rh and Ir Compounds and Study of Their Catalytic Activity, Inorganic Chemistry, Volume 44 (2005) no. 26, p. 9961 | DOI:10.1021/ic051272b
Elena Mas-Marzá; Mercedes Sanaú; Eduardo Peris A new pyridine-bis-N-heterocyclic carbene ligand and its coordination to Rh: Synthesis and characterization, Journal of Organometallic Chemistry, Volume 690 (2005) no. 24-25, p. 5576 | DOI:10.1016/j.jorganchem.2005.04.060
Gurusamy Thangavelu Senthil Andavan; Eike B. Bauer; Christopher S. Letko; T. Keith Hollis; Fook S. Tham Synthesis and characterization of a free phenylene bis(N-heterocyclic carbene) and its di-Rh complex: Catalytic activity of the di-Rh and CCC–NHC Rh pincer complexes in intermolecular hydrosilylation of alkynes, Journal of Organometallic Chemistry, Volume 690 (2005) no. 24-25, p. 5938 | DOI:10.1016/j.jorganchem.2005.07.088
Elena Mas-Marzá; Eduardo Peris; Ingrid Castro-Rodríguez; Karsten Meyer Synthesis and Catalytic Properties of Two Trinuclear Complexes of Rhodium and Iridium with the N-Heterocyclic Tris-carbene Ligand TIMENiPr, Organometallics, Volume 24 (2005) no. 13, p. 3158 | DOI:10.1021/om0501531
Eduardo Peris; Robert H. Crabtree New Routes to Carbene Complexes for Thermally and Oxidatively Robust Homogeneous Catalysts, ChemInform, Volume 35 (2004) no. 20 | DOI:10.1002/chin.200420266
Macarena Poyatos; Elena Mas-Marzá; Mercedes Sanaú; Eduardo Peris Synthesis and Reactivity of New Chelate-N-Heterocyclic Biscarbene Complexes of Ruthenium, Inorganic Chemistry, Volume 43 (2004) no. 5, p. 1793 | DOI:10.1021/ic035307o
Elena Mas-Marzá; Macarena Poyatos; Mercedes Sanaú; Eduardo Peris A New Rhodium(III) Complex with a Tripodal Bis(imidazolylidene) Ligand. Synthesis and Catalytic Properties, Organometallics, Volume 23 (2004) no. 3, p. 323 | DOI:10.1021/om0341552
Fiona McLachlan; Christopher J. Mathews; Paul J. Smith; Tom Welton Palladium-Catalyzed Suzuki Cross-Coupling Reactions in Ambient Temperature Ionic Liquids: Evidence for the Importance of Palladium Imidazolylidene Complexes, Organometallics, Volume 22 (2003) no. 25, p. 5350 | DOI:10.1021/om034075y

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