Fluorine is an indispensable element in modern science and technology, with a ubiquitous presence in our daily lives. Over the last two decades, the interest in fluorinated compounds has grown exponentially, leading to the development of hundreds of thousands of molecules containing at least one fluorine atom. These fluorinated molecules play a vital role across various fields, including life sciences, medicine, pharmacology, medical imaging, and agrochemicals, and finally in materials science.

The diverse applications of fluorinated compounds are vast and impactful. From life-saving drugs, including neuroleptics, anti-cancer agents, and antibiotics, to advanced imaging techniques such as PET scans for the early detection of tumors and neurodegenerative diseases, fluorine is at the heart of many innovations. Fluorine’s contribution is also evident in energy storage and conversion technologies, where it is a critical component in electrodes, electrolytes, and in many polymers, coatings, seals, valves, insulation, etc. Even in the nuclear industry, fluorine is vital for processes such as uranium enrichment via uranium hexafluoride synthesis. These examples underscore fluorine's far-reaching influence on our modern society.

In France, the legacy of fluorine chemistry traces back to pioneers like Henri Moissan and remains a vibrant area of research today. French scientists have made substantial contributions to both organic and inorganic fluorine chemistry, as well as polymer chemistry, with applications spanning from industrial innovation to academic discovery. The creation of the CNRS GIS “Réseau Français Fluor” in 2004 by Alain Tressaud, in collaboration with leading companies such as Solvay (now Syensqo) and Orano, has been a cornerstone in advancing fluorine-related research and development. The network's objectives include fostering collaboration between academia and industry, promoting innovation at the intersection of different fields, and advancing national expertise in fluorine chemistry.

However, the widespread use of fluorinated compounds, particularly per- and polyfluoroalkyl substances (PFAS), presents significant challenges today. PFAS, known for their exceptional stability, have raised environmental concerns due to their persistence, bioaccumulation, and potential toxicity in both humans and wildlife. As awareness of these risks grows, the search for safer, environmentally friendly fluorinated alternatives has become more urgent. The French fluorine network is now playing a critical role in steering this transition toward safer compounds.

In this context, the editorial board of “Compte Rendus Chimie” has decided to dedicate a special issue to showcasing the scientific advancements of fluorine chemists in France. This special issue features 15 outstanding contributions that span the breadth of fluorine chemistry, demonstrating its pivotal role in shaping modern science.

I would like to extend my heartfelt thanks to Prof. Janine Cossy for the kind invitation to edit this special issue and to Julien Desmarets for his invaluable assistance in bringing it to life. My gratitude also goes to all the contributing authors and co-authors for their exceptional work and participation. I trust that this issue will serve as a source of inspiration for readers and spark new collaborations in the flourishing field of fluorine chemistry.

Frédéric Leroux
UMR7042-LIMA
CNRS-Université de Strasbourg
France
frederic.leroux@unistra.fr