Comptes Rendus
no. 3
Voltage addressable nanomemories in DNA?
[Nanomémoires adressables en ADN ?]
Hervé Isambert1
1 Laboratoire de dynamique des fluides complexes, Institut de physique, 3, rue de l'Université, 67000 Strasbourg, France
Comptes Rendus. Physique, Volume 3 (2002) no. 3, pp. 391-396.

Il est possible de concevoir des courtes séquences d'ADN simple-brin présentant plusieurs structures secondaires stables (> heures). En principe, de telles molécules pourraient être utilisées comme des nanomémoires si elles pouvaient être facilement passées d'un état piégé à un autre. Nous proposons ici que le travail nécessaire pour placer la molécule dans un état piégé particulier peut être fourni par sa propre synthèse. Prolongeant cette idée, nous montrons qu'une faible tension (<1 V) pourrait induire le basculement structural d'une molécule bistable à volonté, en la forçant à passer au travers d'un nanopore et à se replier alternativement ensuite à partir de l'une ou l'autre extrémité.

Short single-stranded DNA (or RNA) molecules can be designed to have several long lived (> hours) secondary structures. In principle, such molecules could be used as nanomemories if they could be easily induced to switch between trapped states. We propose here that the necessary work required to drive the molecule into one particular trapped state can be provided by its own synthesis. Following this idea, we argue that a low voltage (<1 V) may induce a bistable DNA molecule to switch structure at will, by forcing it to thread through a nanopore and refold alternatively from either of its ends.

Reçu le :
Révisé le :
Publié le :
DOI : 10.1016/S1631-0705(02)01315-4
Keywords: nanomemory, nanopore, DNA synthesis
Mot clés : nanomémoire, nanopore, synthèse de l'ADN
Hervé Isambert 1

1 Laboratoire de dynamique des fluides complexes, Institut de physique, 3, rue de l'Université, 67000 Strasbourg, France 
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Hervé Isambert. Voltage addressable nanomemories in DNA?. Comptes Rendus. Physique, Volume 3 (2002) no. 3, pp. 391-396. doi : 10.1016/S1631-0705(02)01315-4. https://comptes-rendus.academie-sciences.fr/physique/articles/10.1016/S1631-0705(02)01315-4/

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