Comptes Rendus
Hydrodynamics and physics of soft objects/Hydrodynamique et physique des objets mous
Cell adhesion in cancer
Comptes Rendus. Physique, Volume 4 (2003) no. 2, pp. 289-304.

Cell adhesion is a key physiological event tightly coupled to other major cellular processes coordinating morphogenesis and histogenesis. Cell-to-cell and cell-to-extracellular matrix adhesion regulates the social behavior of cells in developing embryos and in the adult. These two adhesion systems also play a critical role in pathogenesis. In vertebrates, more than 3% of genes are thought to encode adhesion molecules. The largest cell adhesion molecule superfamily is that related to N-CAM, the members of which characteristically contain immunoglobulin domains. Cadherins, which also possess Ig domains, constitute another important superfamily with different properties. Integrins are major receptors for many extracellular matrix components. This review describes the structure and function of these adhesion systems and their impact in cancer invasion and metastasis.

L'adhérence cellulaire est un mécanisme physiologique contrôlant la morphogenèse l'histogenèse et l'intégrité des tissus adultes par son couplage étroit avec les processus de migration, de prolifération, de différenciation et de mort cellulaire. Cette revue rappelle la structure et la fonction des molécules adhésives appartenant à la super famille des immunoglobulines, des cadhérines et des intégrines qui assurent les interactions entre cellules et entre cellules et matrice extracellulaire. Le rôle de ces molécules adhésives est décrit dans les mécanismes de progression des cancers.

Published online:
DOI: 10.1016/S1631-0705(03)00031-8
Keywords: Cell adhesion, CAM-Ig, Cadherins, Integrins, Carcinoma, Progression
Mot clés : Adhérence cellulaire, CAM-Ig, Cadhérines, Intégrines, Carcinomes, Progression

Jean Paul Thiery 1

1 UMR 144 CNRS and Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05, France
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Jean Paul Thiery. Cell adhesion in cancer. Comptes Rendus. Physique, Volume 4 (2003) no. 2, pp. 289-304. doi : 10.1016/S1631-0705(03)00031-8. https://comptes-rendus.academie-sciences.fr/physique/articles/10.1016/S1631-0705(03)00031-8/

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