Conversion of a proton pair para order into <sup>13</sup>C polarization by rf irradiation, for use in MRI

Maurice Goldman; Haukur Jóhannesson

doi:10.1016/j.crhy.2005.03.002

Physics/Applied physics

Conversion of a proton pair para order into ¹³C polarization by rf irradiation, for use in MRI

Presented by: Maurice Goldman

Maurice Goldman ¹ ; Haukur Jóhannesson ²

¹ 6, résidence de Villebon, 91191 Villebon-sur-Yvette, France
² GE Healthcare Bio-Sciences, Medeon, 20512 Malmö, Sweden

Comptes Rendus. Physique, Aircraft trailing vortices, Volume 6 (2005) no. 4-5, pp. 575-581.

Abstract
Résumé

We describe the theory of production of hyperpolarized ¹³C in small organic molecules, for use as molecular contrast agents in MRI, by a two-step process. The first is a catalyzed hydrogenation with para-hydrogen in a small dc magnetic field under rf irradiation, resulting in a molecular proton pair in the pure para state. The second step converts this para order into net hyperpolarization of a nearby carbon 13 through a sequence of rf pulses at the resonance frequencies of both spin species. The final theoretical polarization is close to unity. The whole process, which was successfully implemented, takes a few seconds.

Nous décrivons la théorie de la production de carbone 13 hyper polarisé dans des petites molécules organiques marquées, pour utilisation comme agents de contraste moléculaires en IRM, par un processus en deux grandes étapes. La première est une hydrogénation catalytique avec de l'hydrogène para dans un petit champ magnétique statique sous irradition de radiofréquence, dont l'effet est de produire une paire de protons moléculaires dans un pur état para. La seconde étape convertit cet ordre para en hyperpolarisation globale d'un carbone 13 voisin par une séquence d'impulsions de radiofréquence aux fréquences de résonance des deux espèces de spins. La polarisation théorique finale est proche de l'unité. Le processus, mis en œuvre avec succès, ne dure que quelques secondes.

Received: 2005-02-21
Accepted: 2005-03-10
Published online: 2005-04-27

DOI: 10.1016/j.crhy.2005.03.002

Keywords: Induced polarization, Para-hydrogen, Rf pulses, MRI
Mots-clés : Polarisation induite, Para hydrogène, Impulsions de radiofréquence, IRM

Author's affiliations:

Maurice Goldman ¹; Haukur Jóhannesson ²

¹ 6, résidence de Villebon, 91191 Villebon-sur-Yvette, France
² GE Healthcare Bio-Sciences, Medeon, 20512 Malmö, Sweden

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     author = {Maurice Goldman and Haukur J\'ohannesson},
     title = {Conversion of a proton pair para order into {\protect\textsuperscript{13}C} polarization by rf irradiation, for use in {MRI}},
     journal = {Comptes Rendus. Physique},
     pages = {575--581},
     publisher = {Elsevier},
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     year = {2005},
     doi = {10.1016/j.crhy.2005.03.002},
     language = {en},
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Maurice Goldman; Haukur Jóhannesson. Conversion of a proton pair para order into ¹³C polarization by rf irradiation, for use in MRI. Comptes Rendus. Physique, Aircraft trailing vortices, Volume 6 (2005) no. 4-5, pp. 575-581. doi : 10.1016/j.crhy.2005.03.002. https://comptes-rendus.academie-sciences.fr/physique/articles/10.1016/j.crhy.2005.03.002/

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