Comptes Rendus
Bidirectional control—a unifying view of the structure and function of proteins
Comptes Rendus. Physique, Volume 8 (2007) no. 5-6, pp. 650-660.

The chemo-mechanical cycles of a single head of myosin and that of kinesin are analyzed qualitatively, based on the framework of the bidirectional control for autonomous systems working under thermal and chemical fluctuations [K. Sekimoto, Physica D 205 (2005) 242]. This framework supposes two allosteric coordinates each joining a sensor with a gate. The analysis shows a fundamental parallelism between these motors, despite the apparent differences, with a common hidden symmetry-breaking of the chemo-mechanical cycles. The results give insights into the structure–function relationship of these motor proteins.

Les cycles chimio-mécaniques d'une seule tête de myosine et ceux de la kinésine sont analysés qualitativement sur base du schéma du contrôle bidirectionnel pour les systèmes autonomes fonctionnant sous des fluctuations thermiques et chimiques [K. Sekimoto, Physica D 205 (2005) 242]. Ce schéma suppose deux coordonnées allostériques chacune joignant un senseur avec une porte. L'analyse montre un parallélisme fondamental entre ces moteurs en dépit de différences apparentes, avec une commune brisure de symétrie cachée des cycles chimio-mécaniques. Les résultats donnent une perspective sur la relation entre la structure et la fonction de ces protéines motrices.

Received:
Published online:
DOI: 10.1016/j.crhy.2007.05.009
Keywords: Autonomous system, Molecular motor, Bidirectional control
Mot clés : Système autonome, Moteur moléculaire, Contrôle bidirectionnel

Ken Sekimoto 1, 2

1 Matières et systèmes complexes – CNRS/UMR7057, université Paris 7, 10, rue Alice-Domon et Léonie-Duquet, 75205 Paris cedex 13, France
2 Gulliver – CNRS/UMR7083, ESPCI, 10, rue Vauquelin, 75231 Paris cedex 05, France
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Ken Sekimoto. Bidirectional control—a unifying view of the structure and function of proteins. Comptes Rendus. Physique, Volume 8 (2007) no. 5-6, pp. 650-660. doi : 10.1016/j.crhy.2007.05.009. https://comptes-rendus.academie-sciences.fr/physique/articles/10.1016/j.crhy.2007.05.009/

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