Comptes Rendus
no. 5
Microfluidic separation process by the Soret effect in biological fluids
Alain Martin1  ; M. Mounir Bou-Ali1  ; Haritz Barrutia1  ; David Alonso de Mezquia1
1 MGEP Mondragon Goi Eskola Politeknikoa, Mechanical and Industrial Manufacturing Department, Loramendi 4, Apdo. 23, 20500 Mondragon, Spain
Comptes Rendus. Mécanique, Volume 339 (2011) no. 5, pp. 342-348.

In this article the thermophysical and transport properties of mixtures composed of glucose and sucrose in dimethylsulfoxide (DMSO) are determined. The studied mass concentrations are 5%, 10%, 15%, 20% and 25% of glucose or sucrose in DMSO at an average temperature of 25 °C. The properties studied experimentally are the dynamic viscosity, density, mass and thermal expansion coefficient and thermodiffusion coefficient. The thermogravitational technique in flat configuration is used in order to obtain the thermodiffusion coefficients. Once these properties are known, the work is focused on the numerical study of applying a temperature gradient in microdevices in order to optimize the extraction of DMSO using the CFD Ansys Fluent software. The results show an improvement even of 35% on microfluidic separation techniques that are based on a purely diffusive regime.

Publié le :
DOI : 10.1016/j.crme.2011.03.012
Mots clés : Microfluidics, Molecular diffusion, Biotechnology, Soret effect, Microseparation
Alain Martin 1 ; M. Mounir Bou-Ali 1 ; Haritz Barrutia 1 ; David Alonso de Mezquia 1

1 MGEP Mondragon Goi Eskola Politeknikoa, Mechanical and Industrial Manufacturing Department, Loramendi 4, Apdo. 23, 20500 Mondragon, Spain 
@article{CRMECA_2011__339_5_342_0,
     author = {Alain Martin and M. Mounir Bou-Ali and Haritz Barrutia and David Alonso de Mezquia},
     title = {Microfluidic separation process by the {Soret} effect in biological fluids},
     journal = {Comptes Rendus. M\'ecanique},
     pages = {342--348},
     publisher = {Elsevier},
     volume = {339},
     number = {5},
     year = {2011},
     doi = {10.1016/j.crme.2011.03.012},
     language = {en},
}
TY  - JOUR
AU  - Alain Martin
AU  - M. Mounir Bou-Ali
AU  - Haritz Barrutia
AU  - David Alonso de Mezquia
TI  - Microfluidic separation process by the Soret effect in biological fluids
JO  - Comptes Rendus. Mécanique
PY  - 2011
SP  - 342
EP  - 348
VL  - 339
IS  - 5
PB  - Elsevier
DO  - 10.1016/j.crme.2011.03.012
LA  - en
ID  - CRMECA_2011__339_5_342_0
ER  - 
%0 Journal Article
%A Alain Martin
%A M. Mounir Bou-Ali
%A Haritz Barrutia
%A David Alonso de Mezquia
%T Microfluidic separation process by the Soret effect in biological fluids
%J Comptes Rendus. Mécanique
%D 2011
%P 342-348
%V 339
%N 5
%I Elsevier
%R 10.1016/j.crme.2011.03.012
%G en
%F CRMECA_2011__339_5_342_0
Alain Martin; M. Mounir Bou-Ali; Haritz Barrutia; David Alonso de Mezquia. Microfluidic separation process by the Soret effect in biological fluids. Comptes Rendus. Mécanique, Volume 339 (2011) no. 5, pp. 342-348. doi : 10.1016/j.crme.2011.03.012. https://comptes-rendus.academie-sciences.fr/mecanique/articles/10.1016/j.crme.2011.03.012/

[1] J. Köhler; M.T. Henkel Chip devices for miniaturized biotechnology, Appl. Microbiol. Biotechno., Volume 69 (2005), pp. 113-125

[2] K.K. Fleming; E.K. Longmire; A. Hubel Numerical characterization of diffusion-based extraction in cell-laden flow through a microfluidic channel, Journal of Biomechanical Engineering, Volume 129 (2007), pp. 703-711

[3] C. Mata; E.K. Longmire; D.H. McKenna; K.K. Glass; A. Hubel Experimental study of diffusion-based extraction from a cell suspension, Microfluid Nanofluid, Volume 5 (2008), pp. 529-540

[4] K.K. Fleming; E.K. Longmire; A. Hubel Optimization of a microfluidic device for diffusion-based extraction of DMSO from a cell suspension, International Journal of Heat and Mass Transfer, Volume 51 (2008), pp. 5749-5757

[5] J.K. Platten; M.M. Bou-Ali; P. Blanco; J.A. Madariaga; C.J. Santamaria Phys. Chem. B, 111 (2007), pp. 11524-11530

[6] A. Torreggiani; M. Di Foggia; I. Manco; S.A. Markarian; S. Bonora Effect of sulfoxides on the thermal denaturation of hen lysozyme: A calorimetric and Raman study, Journal of Molecular Structure, Volume 891 (2008), pp. 115-122

[7] N.H. Chao; C.P. Chiang; H.W. Hsu; C.T. Tsai; T.T. Lin Toxicity tolerance of oyster embryos to selected cryoprotectants, Aquat. Living Resour., Volume 7 (1994), pp. 99-104

[8] V. Antonenas; K. Bradstock; P. Shaw Effect of washing procedures on unrelated cord blood units for transplantation in children and adults, Cytotherapy, Volume 4 (2002), p. 16

[9] J.K. Platten; M.M. Bou-Ali; P. Costeseque; J.K. Dutrieux; W. Köhler; C. Leppla; S. Wiegand; G. Wittko Benchmark values for the Soret, thermal diffusion and diffusion coefficients of three binary organic liquid mixtures, Philosophical Magazine, Volume 83 (2003), pp. 1965-1971

[10] M.M. Bou-Ali; J.J. Valenciaga; J.A. Madariaga; C. Santamaría; O. Ecenarro; J.K. Dutrieux Determination of the thermodiffusion coefficient in three binary organic liquid mixtures by the thermogravitational method, Philosophical Magazine, Volume 83 (2003), pp. 2011-2015

[11] M.M. Bou-Ali; O. Ecenarro; J.A. Madariaga; C.M. Santamaría; J.J. Valencia Thermogravitational measurement of the Soret coefficient of liquid mixtures, Journal of Physics, Volume 10 (1998), pp. 3321-3331

[12] Fluent, Fluent Inc., Version 6.3.26, 2006.

[13] H. Barrutia, A. Martin, A. Zebib, M.M. Bou-Ali, Thermal diffusion effects in T-shaped micromixers, in: 1st European Conference on Microfluidics, Bologna, 2008.

[14] S.R. De Groot; P. Mazur Non-Equilibrium Thermodynamics, North-Holland Pub. Co., Amsterdam, 1962

Cité par Sources :

Commentaires - Politique

Ces articles pourraient vous intéresser

Validity limits of the FJO thermogravitational column theory: Experimental and numerical analysis

Jose Antonio Madariaga; Carlos Santamaria; Haritz Barrutia; ...

C. R. Méca (2011)

Determination of thermal diffusion coefficient of nanofluid: Fullerene–toluene

Alain Martin; M. Mounir Bou-Ali

C. R. Méca (2011)