Microfluidic separation process by the Soret effect in biological fluids

Alain Martin; M. Mounir Bou-Ali; Haritz Barrutia; David Alonso de Mezquia

doi:10.1016/j.crme.2011.03.012

Microfluidic separation process by the Soret effect in biological fluids

Alain Martin ¹; M. Mounir Bou-Ali ¹ ; Haritz Barrutia ¹; David Alonso de Mezquia ¹

¹ MGEP Mondragon Goi Eskola Politeknikoa, Mechanical and Industrial Manufacturing Department, Loramendi 4, Apdo. 23, 20500 Mondragon, Spain

Comptes Rendus. Mécanique, Thermodiffusion and coupled phenomena, Volume 339 (2011) no. 5, pp. 342-348.

Abstract

In this article the thermophysical and transport properties of mixtures composed of glucose and sucrose in dimethylsulfoxide (DMSO) are determined. The studied mass concentrations are 5%, 10%, 15%, 20% and 25% of glucose or sucrose in DMSO at an average temperature of 25 °C. The properties studied experimentally are the dynamic viscosity, density, mass and thermal expansion coefficient and thermodiffusion coefficient. The thermogravitational technique in flat configuration is used in order to obtain the thermodiffusion coefficients. Once these properties are known, the work is focused on the numerical study of applying a temperature gradient in microdevices in order to optimize the extraction of DMSO using the CFD Ansys Fluent software. The results show an improvement even of 35% on microfluidic separation techniques that are based on a purely diffusive regime.

Published online: 2011-04-22

DOI: 10.1016/j.crme.2011.03.012

Keywords: Microfluidics, Molecular diffusion, Biotechnology, Soret effect, Microseparation

Author's affiliations:

Alain Martin ¹; M. Mounir Bou-Ali ¹; Haritz Barrutia ¹; David Alonso de Mezquia ¹

¹ MGEP Mondragon Goi Eskola Politeknikoa, Mechanical and Industrial Manufacturing Department, Loramendi 4, Apdo. 23, 20500 Mondragon, Spain

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     author = {Alain Martin and M. Mounir Bou-Ali and Haritz Barrutia and David Alonso de Mezquia},
     title = {Microfluidic separation process by the {Soret} effect in biological fluids},
     journal = {Comptes Rendus. M\'ecanique},
     pages = {342--348},
     publisher = {Elsevier},
     volume = {339},
     number = {5},
     year = {2011},
     doi = {10.1016/j.crme.2011.03.012},
     language = {en},
}

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Alain Martin; M. Mounir Bou-Ali; Haritz Barrutia; David Alonso de Mezquia. Microfluidic separation process by the Soret effect in biological fluids. Comptes Rendus. Mécanique, Thermodiffusion and coupled phenomena, Volume 339 (2011) no. 5, pp. 342-348. doi : 10.1016/j.crme.2011.03.012. https://comptes-rendus.academie-sciences.fr/mecanique/articles/10.1016/j.crme.2011.03.012/

References
Cited by

[1] J. Köhler; M.T. Henkel Chip devices for miniaturized biotechnology, Appl. Microbiol. Biotechno., Volume 69 (2005), pp. 113-125

[2] K.K. Fleming; E.K. Longmire; A. Hubel Numerical characterization of diffusion-based extraction in cell-laden flow through a microfluidic channel, Journal of Biomechanical Engineering, Volume 129 (2007), pp. 703-711

[3] C. Mata; E.K. Longmire; D.H. McKenna; K.K. Glass; A. Hubel Experimental study of diffusion-based extraction from a cell suspension, Microfluid Nanofluid, Volume 5 (2008), pp. 529-540

[4] K.K. Fleming; E.K. Longmire; A. Hubel Optimization of a microfluidic device for diffusion-based extraction of DMSO from a cell suspension, International Journal of Heat and Mass Transfer, Volume 51 (2008), pp. 5749-5757

[5] J.K. Platten; M.M. Bou-Ali; P. Blanco; J.A. Madariaga; C.J. Santamaria Phys. Chem. B, 111 (2007), pp. 11524-11530

[6] A. Torreggiani; M. Di Foggia; I. Manco; S.A. Markarian; S. Bonora Effect of sulfoxides on the thermal denaturation of hen lysozyme: A calorimetric and Raman study, Journal of Molecular Structure, Volume 891 (2008), pp. 115-122

[7] N.H. Chao; C.P. Chiang; H.W. Hsu; C.T. Tsai; T.T. Lin Toxicity tolerance of oyster embryos to selected cryoprotectants, Aquat. Living Resour., Volume 7 (1994), pp. 99-104

[8] V. Antonenas; K. Bradstock; P. Shaw Effect of washing procedures on unrelated cord blood units for transplantation in children and adults, Cytotherapy, Volume 4 (2002), p. 16

[9] J.K. Platten; M.M. Bou-Ali; P. Costeseque; J.K. Dutrieux; W. Köhler; C. Leppla; S. Wiegand; G. Wittko Benchmark values for the Soret, thermal diffusion and diffusion coefficients of three binary organic liquid mixtures, Philosophical Magazine, Volume 83 (2003), pp. 1965-1971

[10] M.M. Bou-Ali; J.J. Valenciaga; J.A. Madariaga; C. Santamaría; O. Ecenarro; J.K. Dutrieux Determination of the thermodiffusion coefficient in three binary organic liquid mixtures by the thermogravitational method, Philosophical Magazine, Volume 83 (2003), pp. 2011-2015

[11] M.M. Bou-Ali; O. Ecenarro; J.A. Madariaga; C.M. Santamaría; J.J. Valencia Thermogravitational measurement of the Soret coefficient of liquid mixtures, Journal of Physics, Volume 10 (1998), pp. 3321-3331

[12] Fluent, Fluent Inc., Version 6.3.26, 2006.

[13] H. Barrutia, A. Martin, A. Zebib, M.M. Bou-Ali, Thermal diffusion effects in T-shaped micromixers, in: 1st European Conference on Microfluidics, Bologna, 2008.

[14] S.R. De Groot; P. Mazur Non-Equilibrium Thermodynamics, North-Holland Pub. Co., Amsterdam, 1962

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