Core-shell configurations are ubiquitous in nature such as in the form of bacterial and cells. Inspired by this, microcapsules are designed with actives as the cores surrounded by thin shells. They not only play an increasing role as artificial models for understanding dynamic behaviors of biological cells in flows, but are also becoming a fundamental class of artificial vehicles at the heart of drug delivery and release in applications. The mechanical properties of the shells are of great importance in this context. Here, we review recent experimental and theoretical characterizations of microcapsules, focusing on the soft and deformable particles with liquid cores. We begin by exploring the concept and fabrication of artificial microcapsules, followed by a discussion of different methods on the mechanical characterization of the shell.
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Kaili Xie 1; Marc Leonetti 2
@article{CRMECA_2023__351_S2_163_0, author = {Kaili Xie and Marc Leonetti}, title = {Mechanical characterization of core-shell microcapsules}, journal = {Comptes Rendus. M\'ecanique}, pages = {163--182}, publisher = {Acad\'emie des sciences, Paris}, volume = {351}, number = {S2}, year = {2023}, doi = {10.5802/crmeca.148}, language = {en}, }
Kaili Xie; Marc Leonetti. Mechanical characterization of core-shell microcapsules. Comptes Rendus. Mécanique, Volume 351 (2023) no. S2, pp. 163-182. doi : 10.5802/crmeca.148. https://comptes-rendus.academie-sciences.fr/mecanique/articles/10.5802/crmeca.148/
[1] Motion and deformation of elastic capsules and vesicles in flow, Annu. Rev. Fluid Mech., Volume 48 (2016), pp. 25-52 | DOI | MR | Zbl
[2] Fabrication and application of complex microcapsules: A review, Soft Matter, Volume 16 (2020) no. 3, pp. 570-590 | DOI
[3] Advances in spray-drying encapsulation of food bioactive ingredients: From microcapsules to nanocapsules, Annual review of food science and technology, Volume 10 (2019), pp. 103-131 | DOI
[4] Polymer microcapsules and microbeads as cell carriers for in vivo biomedical applications, Biomater. Sci., Volume 8 (2020) no. 6, pp. 1536-1574 | DOI
[5] One-step fabrication of ph-responsive membranes and microcapsules through interfacial h-bond polymer complexation, Sci. Rep., Volume 7 (2017) no. 1, 1265 | DOI
[6] Interfacial rheological properties of self-assembling biopolymer microcapsules, Soft matter, Volume 13 (2017) no. 36, pp. 6208-6217 | DOI
[7] Structural characterization of the interfacial self-assembly of chitosan with oppositely charged surfactant, Journal of Colloid and Interface Science, Volume 616 (2022), pp. 911-920 | DOI
[8] Structurally stable sustained-release microcapsules stabilized by self-assembly of pectin-chitosan-collagen in aqueous two-phase system, Food Hydrocolloids, Volume 125 (2022), 107413 | DOI
[9] et al. Biodegradable defined shaped printed polymer microcapsules for drug delivery, ACS Appl. Mater. Interfaces, Volume 13 (2021) no. 2, pp. 2371-2381 | DOI
[10] Fabrication of pH-responsive monodisperse microcapsules using interfacial tension of immiscible phases, Soft Matter, Volume 16 (2020) no. 22, pp. 5139-5147 | DOI
[11] The design of wrinkled microcapsules for enhancement of release rate, Journal of colloid and interface science, Volume 478 (2016), pp. 296-302 | DOI
[12] et al. Deformable and Robust Core-Shell Protein Microcapsules Templated by Liquid–Liquid Phase-Separated Microdroplets, Advanced Materials Interfaces, Volume 8 (2021) no. 19, 2101071 | DOI
[13] Deformation and rupture of microcapsules flowing through constricted capillary, Sci. Rep., Volume 11 (2021) no. 1, 7707 | DOI
[14] Breakups of Chitosan microcapsules in extensional flow, Journal of Colloid and Interface Science, Volume 629 (2023), pp. 445-454 | DOI
[15] Polymeric microcapsules for synthetic applications, Macromolecular bioscience, Volume 8 (2008) no. 11, pp. 991-1005 | DOI
[16] Squeezing bio-capsules into a constriction: deformation till break-up, Soft matter, Volume 13 (2017) no. 41, pp. 7644-7648 | DOI
[17] Mechanical characterization of cross-linked serum albumin microcapsules, Soft matter, Volume 10 (2014) no. 25, pp. 4561-4568 | DOI
[18] Instabilities of microcapsules in flow: breakup and wrinkles, Ph. D. Thesis, Ecole Centrale Marseille, France (2019)
[19] Modeling and simulation of capsules and biological cells, Chapman & Hall/CRC Mathematical and Computational Biology, Chapman & Hall/CRC, 2003 | DOI
[20] Numerical simulation of flowing blood cells, Annu. Rev. Fluid Mech., Volume 46 (2014), pp. 67-95 | DOI | MR | Zbl
[21] Interaction and rheology of vesicle suspensions in confined shear flow, Phys. Rev. Fluids, Volume 2 (2017) no. 10, 103101 | DOI
[22] Blood flow in the microcirculation, Annu. Rev. Fluid Mech., Volume 49 (2017), pp. 443-461 | DOI | MR | Zbl
[23] Direct numerical simulation of cellular-scale blood flow in 3D microvascular networks, Biophys. J., Volume 113 (2017) no. 12, pp. 2815-2826 | DOI
[24] Dynamics of blood cell suspensions in microflows, CRC Press, 2019 | DOI
[25] Comparison of methods for the fabrication and the characterization of polymer self-assemblies: what are the important parameters?, Soft Matter, Volume 12 (2016), pp. 2166-2176 | DOI
[26] Properties of giant vesicles, Current Opinion in Colloid & Interface science, Volume 5 (2000) no. 3-4, pp. 256-263 | DOI
[27] Vesicles and red blood cells in flow: From individual dynamics to rheology, C. R. Physique, Volume 10 (2009) no. 8, pp. 775-789 | DOI
[28] The minimum energy of bending as a possible explanation of the biconcave shape of the human red blood cell, J. Theor. Biol., Volume 26 (1970) no. 1, pp. 61-81 | DOI
[29] Blood crystal: emergent order of red blood cells under wall-confined shear flow, Phys. Rev. Lett., Volume 120 (2018) no. 26, 268102 | DOI
[30] 3D vesicle dynamics simulations with a linearly triangulated surface, J. Comput. Phys., Volume 230 (2011) no. 4, pp. 1020-1034 | DOI | MR
[31] Elastic Properties of Lipid Bilayers: Theory and Possible Experiments, Z. Naturforsch., C, J. Biosci., Volume 28 (1973) no. 11-12, pp. 693-703 | DOI
[32] Sedimentation of vesicles: from pear-like shapes to microtether extrusion, New J. Phys., Volume 13 (2011) no. 3, 035026 | DOI
[33] Sedimentation-induced tether on a settling vesicle, Phys. Rev. E, Volume 88 (2013) no. 1, 010702 | DOI
[34] Bending resistance and chemically induced moments in membrane bilayers, Biophys. J., Volume 14 (1974) no. 12, pp. 923-931 | DOI
[35] Settling of a vesicle in the limit of quasispherical shapes, J. Fluid Mech., Volume 690 (2012), pp. 227-261 | DOI | MR | Zbl
[36] Shape diagram of vesicles in Poiseuille flow, Phys. Rev. Lett., Volume 108 (2012) no. 17, 178106 | DOI
[37] Elastometry of deflated capsules: Elastic moduli from shape and wrinkle analysis, Langmuir, Volume 29 (2013) no. 40, pp. 12463-12471 | DOI
[38] Free amino group content of serum albumin microcapsules. III. A study at low pH values, International journal of pharmaceutics, Volume 128 (1996) no. 1-2, pp. 197-202 | DOI
[39] Tuneable thickness barriers for composite o/w and w/o capsules, films, and their decoration with particles, Soft Matter, Volume 7 (2011) no. 19, pp. 9206-9215 | DOI
[40] Growth mechanism of polymer membranes obtained by H-bonding across immiscible liquid interfaces, ACS Macro Lett., Volume 10 (2021) no. 2, pp. 204-209 | DOI
[41] Experimental studies of the deformation of a synthetic capsule in extensional flow, J. Fluid Mech., Volume 250 (1993), pp. 587-608 | DOI
[42] Deformation and orientation dynamics of polysiloxane microcapsules in linear shear flow, Soft Matter, Volume 8 (2012) no. 13, pp. 3681-3693 | DOI
[43] Stretching of capsules in an elongation flow, a route to constitutive law, J. Fluid Mech., Volume 767 (2015) | DOI
[44] Spherical capsules in three-dimensional unbounded Stokes flows: effect of the membrane constitutive law and onset of buckling, J. Fluid Mech., Volume 516 (2004), pp. 303-334 | DOI | MR | Zbl
[45] Capsule motion in flow: Deformation and membrane buckling, C. R. Physique, Volume 10 (2009) no. 8, pp. 764-774 | DOI
[46] Effect of constitutive laws for two-dimensional membranes on flow-induced capsule deformation, J. Fluid Mech., Volume 460 (2002), pp. 211-222 | DOI | Zbl
[47] Strain energy function of red blood cell membranes, Biophys. J., Volume 13 (1973) no. 3, pp. 245-264 | DOI
[48] Buckling of spherical capsules, Phys. Rev. E, Volume 84 (2011) no. 4, 046608 | DOI
[49] Mechanical behaviour of micro-capsules and their rupture under compression, Chemical Engineering Science, Volume 142 (2016), pp. 236-243 | DOI
[50] Compression of a capsule: Mechanical laws of membranes with negligible bending stiffness, Phys. Rev. E, Volume 69 (2004) no. 6, 061601 | DOI
[51] Surface forces of the Arbacia egg, Journal of Cellular and Comparative Physiology, Volume 1 (1932) no. 1, pp. 1-9 | DOI
[52] The compressive deformation of multicomponent microcapsules: Influence of size, membrane thickness, and compression speed, Journal of Biomaterials Science, Polymer Edition, Volume 12 (2001) no. 2, pp. 157-170 | DOI
[53] Compression of biocompatible liquid-filled HSA-alginate capsules: Determination of the membrane mechanical properties, Biotechnology and bioengineering, Volume 82 (2003) no. 2, pp. 207-212 | DOI
[54] Deformation and sorting of capsules in a T-junction, J. Fluid Mech., Volume 885 (2020) | DOI
[55] Stresses and small displacements of shallow spherical shells. I, Journal of Mathematics and Physics, Volume 25 (1946) no. 1-4, pp. 80-85 | DOI | MR | Zbl
[56] Modeling atomic force microscopy and shell mechanical properties estimation of coated microbubbles, Soft Matter, Volume 16 (2020) no. 19, pp. 4661-4681 | DOI
[57] Models for the mechanical characterization of core-shell microcapsules under uniaxial deformation, Food Hydrocolloids, Volume 119 (2021), 106762 | DOI
[58] On the Contact Problem of an Inflated Spherical Nonlinear Membrane, J. Appl. Mech., Volume 40 (1973) no. 1, pp. 209-214 | DOI
[59] Microcapsule mechanics: From stability to function, Advances in colloid and interface science, Volume 207 (2014), pp. 65-80 | DOI
[60] Delamination and wrinkling of flexible conductive polymer thin films, Advanced Functional Materials, Volume 31 (2021) no. 21, 2009039 | DOI
[61] Direct measurement of the elastohydrodynamic lift force at the nanoscale, Phys. Rev. Lett., Volume 124 (2020) no. 5, 054502 | DOI
[62] Elastic properties of polyelectrolyte capsules studied by atomic-force microscopy and RICM, Eur. Phys. J. E, Volume 12 (2003) no. 2, pp. 215-221 | DOI
[63] Comparison between measurements of elasticity and free amino group content of ovalbumin microcapsule membranes: discrimination of the cross-linking degree, Journal of colloid and interface science, Volume 355 (2011) no. 1, pp. 81-88 | DOI
[64] Microfluidic in-situ measurement of Poisson’s ratio of hydrogels, Micromachines, Volume 11 (2020) no. 3, p. 318 | DOI
[65] New method for measuring Poisson’s ratio in polymer gels, Journal of applied polymer science, Volume 50 (1993) no. 6, pp. 1107-1111 | DOI
[66] Formation and mechanical characterization of aminoplast core/shell microcapsules, ACS Appl. Mater. Interfaces, Volume 4 (2012) no. 6, pp. 2940-2948 | DOI
[67] Viscoelastic characterization of the crosslinking of -lactoglobulin on emulsion drops via microcapsule compression and interfacial dilational and shear rheology, Journal of colloid and interface science, Volume 583 (2021), pp. 404-413 | DOI
[68] Surface energy and the contact of elastic solids, Proceedings of the royal society of London. A. mathematical and physical sciences, Volume 324 (1971) no. 1558, pp. 301-313 | DOI
[69] Experimental characterisation and modelling of mechanical behaviour of microcapsules, Journal of Materials Science, Volume 55 (2020) no. 27, pp. 13457-13471 | DOI
[70] Study of the influence of actin-binding proteins using linear analyses of cell deformability, Soft Matter, Volume 11 (2015) no. 27, pp. 5435-5446 | DOI
[71] Advances in micropipette aspiration: applications in cell biomechanics, models, and extended studies, Biophys. J., Volume 116 (2019) no. 4, pp. 587-594 | DOI
[72] Finite element simulation of the micropipette aspiration of a living cell undergoing large viscoelastic deformation, Mech. Adv. Mater. Struct., Volume 12 (2005) no. 6, pp. 501-512 | DOI
[73] The Application of a Homogeneous Half-Space Model in the Analysis of Endothelial Cell Micropipette Measurements, J. Biomech. Eng., Volume 110 (1988) no. 3, pp. 190-199 | DOI
[74] Measurement of membrane elasticity by micro-pipette aspiration, Eur. Phys. J. E, Volume 14 (2004) no. 2, pp. 149-167 | DOI
[75] Pendant capsule elastometry, Journal of colloid and interface science, Volume 513 (2018), pp. 549-565 | DOI
[76] Coupling of finite element and boundary integral methods for a capsule in a Stokes flow, Int. J. Numer. Methods Eng., Volume 83 (2010) no. 7, pp. 829-850 | DOI | MR | Zbl
[77] Isogeometric FEM-BEM simulations of drop, capsule and vesicle dynamics in Stokes flow, J. Comput. Phys., Volume 342 (2017), pp. 117-138 | DOI | MR | Zbl
[78] A hybrid method to study flow-induced deformation of three-dimensional capsules, J. Comput. Phys., Volume 227 (2008) no. 12, pp. 6351-6371 | DOI | MR
[79] Modeling deformable capsules in viscous flow using immersed boundary method, Phys. Fluids, Volume 32 (2020) no. 9, 093602 | DOI
[80] Dynamic characteristics of a deformable capsule in a simple shear flow, Phys. Rev. E, Volume 99 (2019) no. 2, 023101 | DOI
[81] Dynamics of strain-hardening and strain-softening capsules in strong planar extensional flows via an interfacial spectral boundary element algorithm for elastic membranes, J. Fluid Mech., Volume 641 (2009), pp. 263-296 | DOI | Zbl
[82] Membrane emulsification for the production of suspensions of uniform microcapsules with tunable mechanical properties, Chemical Engineering Science, Volume 237 (2021), 116567 | DOI
[83] Single-step microfluidic fabrication of soft monodisperse polyelectrolyte microcapsules by interfacial complexation, Lab on a Chip, Volume 14 (2014) no. 18, pp. 3494-3497 | DOI
[84] Microfluidic probing of the complex interfacial rheology of multilayer capsules, Soft matter, Volume 15 (2019) no. 13, pp. 2782-2790 | DOI
[85] The time-dependent deformation of a capsule freely suspended in a linear shear flow, J. Fluid Mech., Volume 113 (1981), pp. 251-267 | DOI | Zbl
[86] Role of membrane viscosity in the orientation and deformation of a spherical capsule suspended in shear flow, J. Fluid Mech., Volume 160 (1985), pp. 119-135 | DOI | MR | Zbl
[87] et al. Boundary integral and singularity methods for linearized viscous flow, Cambridge Texts in Applied Mathematics, Cambridge University Press, 1992 | DOI
[88] Perturbations of the flow induced by a microcapsule in a capillary tube, Fluid Dynamics Research, Volume 49 (2017) no. 3, 035501 | DOI
[89] Characterization of the mechanical properties of cross-linked serum albumin microcapsules: effect of size and protein concentration, Colloid. Polym. Sci., Volume 294 (2016) no. 8, pp. 1381-1389 | DOI
[90] Experimental investigation of a bioartificial capsule flowing in a narrow tube, J. Fluid Mech., Volume 547 (2006), pp. 149-173 | DOI | Zbl
[91] A microfluidic methodology to identify the mechanical properties of capsules: comparison with a microrheometric approach, Flow, Volume 1 (2021) | DOI
[92] Diffuse approximation for identification of the mechanical properties of microcapsules, Mathematics and Mechanics of Solids, Volume 26 (2021) no. 7, pp. 1018-1028 | DOI | MR | Zbl
[93] Shear-induced deformations of polyamide microcapsules, Colloid. Polym. Sci., Volume 278 (2000) no. 2, pp. 169-175 | DOI
[94] From two-dimensional model networks to microcapsules, Rheologica acta, Volume 41 (2002) no. 4, pp. 292-306 | DOI
[95] Synthetic capsule breakup in simple shear flow, Phys. Fluids, Volume 32 (2020) no. 11, 113603 | DOI
[96] Tank-treading of microcapsules in shear flow, J. Fluid Mech., Volume 789 (2016), pp. 750-767 | DOI
[97] The formation of emulsions in definable fields of flow, Proc. R. Soc. Lond. A, Volume 146 (1934) no. 858, pp. 501-523 | DOI
[98] Dynamics of a vesicle in general flow, Proc. Natl. Acad. Sci. USA, Volume 106 (2009) no. 28, pp. 11444-11447 | Zbl
[99] Swinging and synchronized rotations of red blood cells in simple shear flow, Phys. Rev. E, Volume 80 (2009) no. 2, 021902 | DOI
[100] Stabilizing viscous extensional flows using reinforcement learning, Phys. Rev. E, Volume 104 (2021) no. 5, 055108 | DOI | MR
[101] Deformation of giant lipid vesicles by electric fields, Phys. Rev. A, Volume 44 (1991) no. 12, pp. 8356-8360 | DOI
[102] Giant vesicles in electric fields, Soft matter, Volume 3 (2007) no. 7, pp. 817-827 | DOI
[103] Vesicles in electric fields: Some novel aspects of membrane behavior, Soft Matter, Volume 5 (2009) no. 17, pp. 3201-3212 | DOI
[104] The electrohydrodynamic deformation of drops suspended in liquids in steady and oscillatory electric fields, J. Fluid Mech., Volume 239 (1992), pp. 1-21 | DOI
[105] Electrohydrodynamics: a review of the role of interfacial shear stresses, Annu. Rev. Fluid Mech., Volume 1 (1969) no. 1, pp. 111-146 | DOI
[106] A vesicle microrheometer for high-throughput viscosity measurements of lipid and polymer membranes, Biophys. J., Volume 121 (2022) no. 6, pp. 910-918 | DOI
[107] Deformation of an elastic capsule in a uniform electric field, Phys. Fluids, Volume 26 (2014) no. 12, 122108 | DOI
[108] Study of dependence of elasticity on the microstructure of microcapsules using electro-deformation technique, Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 569 (2019), pp. 179-189 | DOI
[109] Large-deformation electrohydrodynamics of an elastic capsule in a DC electric field, J. Fluid Mech., Volume 841 (2018), pp. 489-520 | DOI | MR | Zbl
[110] Influence of surface viscosity on droplets in shear flow, J. Fluid Mech., Volume 791 (2016), pp. 464-494 | DOI | MR | Zbl
[111] A high-throughput method to characterize membrane viscosity of flowing microcapsules, Phys. Fluids, Volume 33 (2021) no. 1, 011906 | DOI
[112] A neural network-based algorithm for high-throughput characterisation of viscoelastic properties of flowing microcapsules, Soft Matter, Volume 17 (2021) no. 15, pp. 4027-4039 | DOI
[113] et al. Comparative study of cell mechanics methods, Nature methods, Volume 15 (2018) no. 7, pp. 491-498 | DOI
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