Centrifugal microencapsulation has been shown to be a promising encapsulation technique, satisfying at the same time many requirements needed for biomedical applications (monodispersity, controlled size, spherical shape, sterile production environment) and allowing a high capsules production rate, using only conventional lab material. Another important advantage of this technology is the ability to process highly viscous biopolymer solutions. The usage of such solutions is desirable in multiple biomedical applications, because they yield capsules with improved mechanical properties (stiffness and yield strength) and with optimised porosity, which increases the immunoprotection in the case of biomaterial encapsulation applied to cell therapy and enhances a prolonged dissolution behaviour in the case of drug delivery applications. However, previous studies have shown that spherical capsules cannot be obtained using highly viscous solutions, and a capsule tail is always present when such solutions are used. This represents a significant limitation of this technology, since capsule shape regularity is an important requirement for various biomedical applications (e.g. cell therapy implants, drug delivery). In this article we propose and validate experimentally an adaptation of the centrifugal microencapsulation, based on the concept of “soft landing” [1]. This technique allows the production of ellipsoidal and spherical capsules using very viscous (typically up to several tens of ) biopolymer solutions.
Révisé le :
Accepté le :
Publié le :
Matei Badalan 1, 2 ; Lucie Adisson 1 ; Arthur Boldron 1 ; Jean-Luc Achard 1, 2 ; Giovanni Ghigliotti 2 ; Guillaume Balarac 2 ; Frédéric Bottausci 1
CC-BY 4.0
@article{CRMECA_2023__351_G1_83_0,
author = {Matei Badalan and Lucie Adisson and Arthur Boldron and Jean-Luc Achard and Giovanni Ghigliotti and Guillaume Balarac and Fr\'ed\'eric Bottausci},
title = {A {Soft} {Landing} {Approach} for the {Centrifugal} {Microgel} {Synthesis} {Process}},
journal = {Comptes Rendus. M\'ecanique},
pages = {83--102},
publisher = {Acad\'emie des sciences, Paris},
volume = {351},
year = {2023},
doi = {10.5802/crmeca.154},
language = {en},
}
TY - JOUR AU - Matei Badalan AU - Lucie Adisson AU - Arthur Boldron AU - Jean-Luc Achard AU - Giovanni Ghigliotti AU - Guillaume Balarac AU - Frédéric Bottausci TI - A Soft Landing Approach for the Centrifugal Microgel Synthesis Process JO - Comptes Rendus. Mécanique PY - 2023 SP - 83 EP - 102 VL - 351 PB - Académie des sciences, Paris DO - 10.5802/crmeca.154 LA - en ID - CRMECA_2023__351_G1_83_0 ER -
%0 Journal Article %A Matei Badalan %A Lucie Adisson %A Arthur Boldron %A Jean-Luc Achard %A Giovanni Ghigliotti %A Guillaume Balarac %A Frédéric Bottausci %T A Soft Landing Approach for the Centrifugal Microgel Synthesis Process %J Comptes Rendus. Mécanique %D 2023 %P 83-102 %V 351 %I Académie des sciences, Paris %R 10.5802/crmeca.154 %G en %F CRMECA_2023__351_G1_83_0
Matei Badalan; Lucie Adisson; Arthur Boldron; Jean-Luc Achard; Giovanni Ghigliotti; Guillaume Balarac; Frédéric Bottausci. A Soft Landing Approach for the Centrifugal Microgel Synthesis Process. Comptes Rendus. Mécanique, Volume 351 (2023), pp. 83-102. doi : 10.5802/crmeca.154. https://comptes-rendus.academie-sciences.fr/mecanique/articles/10.5802/crmeca.154/
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