Amphiphilic block copolymers can self-assemble in water into various stable morphologies which resemble key cell structures, notably filaments and membranes. Filamentous ‘worms’ of copolymer, microns-long, are briefly introduced, and related dynamics of copolymer vesicle ‘polymersomes’ are reviewed. Fluorescence visualization of single worms stretched under flow demonstrates their stability as well as a means to control conformation. Polymersome membranes have been more thoroughly studied, especially copolymer molecular weight effects. We summarize results suggestive of a transition from Rouse-like behavior to entangled chains. Viewed together, the results ask the question: what physics are needed next to mimic cell activities such as crawling?
Les copolymères en bloc amphiphiles peuvent s'auto-assembler dans l'eau selon différentes morphologies, ressemblant à des éléments structuraux clefs de la cellule, notamment les filaments et les membranes. Les « vers » (worms) filamenteux, de la taille du micron, seront brièvement évoqués, puis nous résumerons les propriétés dynamiques des vésicules de copolymers (polymersomes). La visualisation à l'aide de la microscopie à fluorescence de vers seuls, étirés dans un flux, démontre d'une part, leur stabilité et d'autre part, présente un moyen de contrôler leur conformation. Les membranes des polymersomes ont été étudiées en détail, et plus particulièrement les effets de la masse moléculaire du copolymère. Au final, nous résumerons plusieurs résultats qui suggèrent une transition d'un comportement de « rouse-like » à une chaı̂ne enchevêtrée. Une vue d'ensemble des résultats permet de poser une question à savoir quelle est la physique nécessaire pour imiter des activités de la cellule tel que le « rampement » (cell crawling).
Keywords: Vésicules, Worm micelles, Bloc copolymère, Polymersome
Paul Dalhaimer 1 ; Frank S. Bates 2 ; Helim Aranda-Espinoza 1 ; Dennis Discher 1
@article{CRPHYS_2003__4_2_251_0,
author = {Paul Dalhaimer and Frank S. Bates and Helim Aranda-Espinoza and Dennis Discher},
title = {Synthetic cell elements from block copolymers {\textendash} hydrodynamic aspects},
journal = {Comptes Rendus. Physique},
pages = {251--258},
publisher = {Elsevier},
volume = {4},
number = {2},
year = {2003},
doi = {10.1016/S1631-0705(03)00028-8},
language = {en},
}
TY - JOUR AU - Paul Dalhaimer AU - Frank S. Bates AU - Helim Aranda-Espinoza AU - Dennis Discher TI - Synthetic cell elements from block copolymers – hydrodynamic aspects JO - Comptes Rendus. Physique PY - 2003 SP - 251 EP - 258 VL - 4 IS - 2 PB - Elsevier DO - 10.1016/S1631-0705(03)00028-8 LA - en ID - CRPHYS_2003__4_2_251_0 ER -
%0 Journal Article %A Paul Dalhaimer %A Frank S. Bates %A Helim Aranda-Espinoza %A Dennis Discher %T Synthetic cell elements from block copolymers – hydrodynamic aspects %J Comptes Rendus. Physique %D 2003 %P 251-258 %V 4 %N 2 %I Elsevier %R 10.1016/S1631-0705(03)00028-8 %G en %F CRPHYS_2003__4_2_251_0
Paul Dalhaimer; Frank S. Bates; Helim Aranda-Espinoza; Dennis Discher. Synthetic cell elements from block copolymers – hydrodynamic aspects. Comptes Rendus. Physique, Volume 4 (2003) no. 2, pp. 251-258. doi : 10.1016/S1631-0705(03)00028-8. https://comptes-rendus.academie-sciences.fr/physique/articles/10.1016/S1631-0705(03)00028-8/
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