[Comportement des globules rouges dans un écoulement microconfiné in vitro]
La grande déformabilité des globules rouges (GR) est essentielle pour optimiser les échanges gazeux entre le gaz et la microcirculation dans les tissus in vivo. Cette revue est focalisée sur le comportement des GR dans le flux confiné in vitro, tels que les capillaires à section circulaire, et les canaux rectangulaire, où au moins une dimension transversale est comparable à la taille des cellules. Résultats expérimentaux sur la vitesse et la forme des GR sont examinés conjointement avec prédictions des modèles et des simulations numériques. En dépit des progrès accomplis à ce jour, les conséquences physiopathologiques des modifications de la déformabilité des GR sont pas encore pleinement élucidées, et autres données expérimentales et de modélisation sont nécessaires. Les directions futures comprennent les nouvelles techniques d'application de la microfluidique pour enquêter sur le flux des GR dans des géométries complexes.
The high red blood cell (RBC) deformability is essential to optimal gas exchange between gas and tissues in microcirculation in vivo. This review is focused on the flow behavior of RBCs in microconfined geometries in vitro, such as circular section capillaries, rectangular channels and pores, where at least one transverse dimension is comparable to cell size. Experimental results on RBC velocity and shape are reviewed together with modeling predictions and numerical simulations. In spite of the progress made so far, the pathophysiological implications of altered RBC deformability are still to be fully elucidated, and more data from clinically-relevant experimental methods and modeling-based interpretation are needed. Future directions include the emerging application of microfluidics techniques to investigate RBC flow in complex geometries.
Mots-clés : Globules rouges, Déformabilité, Capillaries, Microfluidique
Stefano Guido 1 ; Giovanna Tomaiuolo 1
@article{CRPHYS_2009__10_8_751_0,
author = {Stefano Guido and Giovanna Tomaiuolo},
title = {Microconfined flow behavior of red blood cells \protect\emph{in vitro}},
journal = {Comptes Rendus. Physique},
pages = {751--763},
publisher = {Elsevier},
volume = {10},
number = {8},
year = {2009},
doi = {10.1016/j.crhy.2009.10.002},
language = {en},
}
Stefano Guido; Giovanna Tomaiuolo. Microconfined flow behavior of red blood cells in vitro. Comptes Rendus. Physique, Complex and biofluids, Volume 10 (2009) no. 8, pp. 751-763. doi : 10.1016/j.crhy.2009.10.002. https://comptes-rendus.academie-sciences.fr/physique/articles/10.1016/j.crhy.2009.10.002/
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