Comptes Rendus
no. 8
Microconfined flow behavior of red blood cells in vitro
[Comportement des globules rouges dans un écoulement microconfiné in vitro]
Stefano Guido1  ; Giovanna Tomaiuolo1
1 Dipartimento di Ingegneria chimica, Università di Napoli Federico II, 80125 Napoli, Italy
Comptes Rendus. Physique, Complex and biofluids, Volume 10 (2009) no. 8, pp. 751-763.

La grande déformabilité des globules rouges (GR) est essentielle pour optimiser les échanges gazeux entre le gaz et la microcirculation dans les tissus in vivo. Cette revue est focalisée sur le comportement des GR dans le flux confiné in vitro, tels que les capillaires à section circulaire, et les canaux rectangulaire, où au moins une dimension transversale est comparable à la taille des cellules. Résultats expérimentaux sur la vitesse et la forme des GR sont examinés conjointement avec prédictions des modèles et des simulations numériques. En dépit des progrès accomplis à ce jour, les conséquences physiopathologiques des modifications de la déformabilité des GR sont pas encore pleinement élucidées, et autres données expérimentales et de modélisation sont nécessaires. Les directions futures comprennent les nouvelles techniques d'application de la microfluidique pour enquêter sur le flux des GR dans des géométries complexes.

The high red blood cell (RBC) deformability is essential to optimal gas exchange between gas and tissues in microcirculation in vivo. This review is focused on the flow behavior of RBCs in microconfined geometries in vitro, such as circular section capillaries, rectangular channels and pores, where at least one transverse dimension is comparable to cell size. Experimental results on RBC velocity and shape are reviewed together with modeling predictions and numerical simulations. In spite of the progress made so far, the pathophysiological implications of altered RBC deformability are still to be fully elucidated, and more data from clinically-relevant experimental methods and modeling-based interpretation are needed. Future directions include the emerging application of microfluidics techniques to investigate RBC flow in complex geometries.

Publié le :
DOI : 10.1016/j.crhy.2009.10.002
Keywords: Red blood cell, Deformability, Microcapillary, Microfluidics
Mots-clés : Globules rouges, Déformabilité, Capillaries, Microfluidique

Stefano Guido 1 ; Giovanna Tomaiuolo 1

1 Dipartimento di Ingegneria chimica, Università di Napoli Federico II, 80125 Napoli, Italy 
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Stefano Guido; Giovanna Tomaiuolo. Microconfined flow behavior of red blood cells in vitro. Comptes Rendus. Physique, Complex and biofluids, Volume 10 (2009) no. 8, pp. 751-763. doi : 10.1016/j.crhy.2009.10.002. https://comptes-rendus.academie-sciences.fr/physique/articles/10.1016/j.crhy.2009.10.002/

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  • Luca Lanotte; Giovanna Tomaiuolo; Chaouqi Misbah; Lionel Bureau; Stefano Guido Red blood cell dynamics in polymer brush-coated microcapillaries: A model of endothelial glycocalyx in vitro, Biomicrofluidics, Volume 8 (2014) no. 1 | DOI:10.1063/1.4863723
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  • Ji Young Moon; Sasidhar Kondaraju; Wonjae Choi; Joon Sang Lee Lattice Boltzmann-immersed boundary approach for vesicle navigation in microfluidic channel networks, Microfluidics and Nanofluidics, Volume 17 (2014) no. 6, p. 1061 | DOI:10.1007/s10404-014-1393-z
  • Alexander Farutin; Chaouqi Misbah Symmetry breaking and cross-streamline migration of three-dimensional vesicles in an axial Poiseuille flow, Physical Review E, Volume 89 (2014) no. 4 | DOI:10.1103/physreve.89.042709
  • Othmane Aouane; Marine Thiébaud; Abdelilah Benyoussef; Christian Wagner; Chaouqi Misbah Vesicle dynamics in a confined Poiseuille flow: From steady state to chaos, Physical Review E, Volume 90 (2014) no. 3 | DOI:10.1103/physreve.90.033011
  • Marine Thiébaud; Zaiyi Shen; Jens Harting; Chaouqi Misbah Prediction of Anomalous Blood Viscosity in Confined Shear Flow, Physical Review Letters, Volume 112 (2014) no. 23 | DOI:10.1103/physrevlett.112.238304
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  • Laura Small; Fatemeh Hassanipour Bio-Inspired Segmented Flow: Effect of Particle Elongation on the Heat Transfer, Journal of Heat Transfer, Volume 135 (2013) no. 7 | DOI:10.1115/1.4024062
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  • Alexander Farutin; Chaouqi Misbah Analytical and Numerical Study of Three Main Migration Laws for Vesicles Under Flow, Physical Review Letters, Volume 110 (2013) no. 10 | DOI:10.1103/physrevlett.110.108104
  • Jonathan B. Freund The flow of red blood cells through a narrow spleen-like slit, Physics of Fluids, Volume 25 (2013) no. 11 | DOI:10.1063/1.4819341
  • Xuejin Li; Petia M. Vlahovska; George Em Karniadakis Continuum- and particle-based modeling of shapes and dynamics of red blood cells in health and disease, Soft Matter, Volume 9 (2013) no. 1, p. 28 | DOI:10.1039/c2sm26891d
  • Yang Li; Eugenia Kumacheva; Arun Ramachandran The motion of a microgel in an axisymmetric constriction with a tapered entrance, Soft Matter, Volume 9 (2013) no. 43, p. 10391 | DOI:10.1039/c3sm51594j
  • Chaouqi Misbah Vesicles, capsules and red blood cells under flow, Journal of Physics: Conference Series, Volume 392 (2012), p. 012005 | DOI:10.1088/1742-6596/392/1/012005
  • Bojan Božič; Gregor Gomišček Role of red blood cell elastic properties in capillary occlusions, Physical Review E, Volume 86 (2012) no. 5 | DOI:10.1103/physreve.86.051902
  • Giovanni Ghigliotti; Hassib Selmi; Lassaad El Asmi; Chaouqi Misbah Why and how does collective red blood cells motion occur in the blood microcirculation?, Physics of Fluids, Volume 24 (2012) no. 10 | DOI:10.1063/1.4757394
  • Giovanna Tomaiuolo; Luca Lanotte; Giovanni Ghigliotti; Chaouqi Misbah; Stefano Guido Red blood cell clustering in Poiseuille microcapillary flow, Physics of Fluids, Volume 24 (2012) no. 5 | DOI:10.1063/1.4721811
  • Vladimir Leble; Rui Lima; Ricardo Dias; Carla Fernandes; Takuji Ishikawa; Yohsuke Imai; Takami Yamaguchi Asymmetry of red blood cell motions in a microchannel with a diverging and converging bifurcation, Biomicrofluidics, Volume 5 (2011) no. 4 | DOI:10.1063/1.3672689
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  • Giovanna Tomaiuolo; Stefano Guido Start-up shape dynamics of red blood cells in microcapillary flow, Microvascular Research, Volume 82 (2011) no. 1, p. 35 | DOI:10.1016/j.mvr.2011.03.004
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