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Comptes Rendus. Physique
Sub-picosecond C=C bond photo-isomerization: evidence for the role of excited state mixing
Comptes Rendus. Physique, Volume 22 (2021) no. S2, pp. 111-138.

Part of the special issue: Physics of ultra-fast phenomena

Sub-picosecond photo-isomerization is the major primary process of energy conversion in retinal proteins and has as such been in the focus of extensive theoretical and experimental work over the past decades. In this review article, we revisit the long-standing question as to how the protein tunes the isomerization speed and quantum yield. We focus on our recent contributions to this field, which underscore the concept of a delicate mixing of reactive and non-reactive excited states, as a result of steric properties and electrostatic interactions with the protein environment. Further avenues and new approaches are outlined which hold promise for advancing our understanding of these intimately coupled chromophore–protein systems.

La photo-isomérisation sub-picoseconde est la principale réaction initiant la conversion d’énergie dans les protéines de rétinal, si bien qu’elle fait l’objet de travaux théoriques et expérimentaux approfondis depuis plus de trente ans. Dans cet article de revue, nous revisitons la question toujours ouverte de savoir comment la protéine détermine la vitesse d’isomérisation et son rendement quantique. A la lumière de nos contributions récentes en ce domaine, nous décrivons le concept d’un mélange d’états excités réactifs et non-réactifs, délicatement ajusté par les interactions stériques et électrostatiques avec l’environnement protéique. De nouvelles perspectives et approches prometteuses sont décrites qui pourront faire progresser la compréhension de ces systèmes chromophore–protéine intimement couplés.

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Published online:
DOI: 10.5802/crphys.41
Keywords: Photo-isomerisation, Retinal proteins, Chromophore–protein coupling, Non-adiabatic dynamics, Photo-sensory proteins, Charge transfer state
Damianos Agathangelou 1; Partha Pratim Roy 2; María del Carmen Marín 3; Nicolas Ferré 4; Massimo Olivucci 3, 5; Tiago Buckup 2; Jérémie Léonard 1; Stefan Haacke 1

1 Université de Strasbourg – CNRS, Institut de Physique et Chimie des Matériaux de Strasbourg, 67034 Strasbourg, France
2 Physikalisch-Chemisches Institut, Ruprecht-Karls Universität Heidelberg, 69120 Heidelberg, Germany
3 Biotechnology, Pharmacy and Chemistry Department, University of Siena, Siena 53100, Italy
4 Aix-Marseille Univ. – CNRS, ICR, 13397 Marseille, France
5 Chemistry Department, Bowling Green State University, Bowling Green, Ohio 43403, USA
License: CC-BY 4.0
Copyrights: The authors retain unrestricted copyrights and publishing rights
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Damianos Agathangelou; Partha Pratim Roy; María del Carmen Marín; Nicolas Ferré; Massimo Olivucci; Tiago Buckup; Jérémie Léonard; Stefan Haacke. Sub-picosecond C$=$C bond photo-isomerization: evidence for the role of excited state mixing. Comptes Rendus. Physique, Volume 22 (2021) no. S2, pp. 111-138. doi : 10.5802/crphys.41. https://comptes-rendus.academie-sciences.fr/physique/articles/10.5802/crphys.41/

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